张育芳

【摘要】 目的：研究阿托伐他汀聯合快步运动对颈动脉粥样硬化患者血脂水平的影响。方法：选取2018年1月-2019年1月笔者所在医院颈动脉斑块患者168例，按随机数字表法分为对照组（n=84）研究组（n=84）。对照组予以阿托伐他汀钙片治疗，研究组予以阿托伐他汀联合快步运动治疗。比较两组治疗12个月后斑块情况、血脂指标及不良反应。结果：治疗后研究组内膜中层厚度低于对照组，斑块面积小于对照组，斑块数少于对照组，差异均有统计学意义（P<0.05）。治疗后研究组三酰甘油（TG）、胆固醇（TC）、低密度脂蛋白（LDL-C）水平均低于对照组，高密度脂蛋白（HDL-C）水平高于对照组，差异均有统计学意义（P<0.05）。研究组不良反应发生率低于对照组，差异有统计学意义（P<0.05）。结论：阿托伐他汀联合快步运动可以改善颈动脉粥样硬化患者的血管弹性，缩小斑块面积及减少斑块数量，降低血脂，帮助减少药物的不良反应。

【关键词】 阿托伐他汀钙片 快步运动 颈动脉粥样硬化 血脂水平

doi：10.14033/j.cnki.cfmr.2020.19.048 文献标识码 B 文章编号 1674-6805（2020）19-0-03

Effects of Atorvastatin Combined with Fast Walking Exercise on the Levels of LDL-C， TC， TG and HDL-C in Patients with Carotid Atherosclerosis/ZHANG Yufang. //Chinese and Foreign Medical Research， 2020， 18（19）： -120

[Abstract] Objective： To study the effect of Atorvastatin combined with fast walking exercise on blood lipid levels in carotid atherosclerosis patients. Method： A total of 168 carotid atherosclerosis patients in our hospital from January 2018 to January 2019 were selected and divided into the control group （n=84） and the study group （n=84） according to random number table method. The control group was treated with Atorvastatin Calcium Tablets， and the study group was treated with Atorvastatin Combined with fast walking exercise. The plaque condition， lipid index and adverse reactions of the two groups were compared after 12 months of treatment. Result： After treatment， the intima-media thickness of the study group was lower than that of the control group， the plaque area was smaller than that of the control group， and the number of plaques in the study group was less than that of the control group， and the differences were statistically significant （P<0.05）. After treatment， the levels of triacylglycerol （TG）， cholesterol （TC）， low density lipoprotein （LDL-C） in the study group were all lower than those in the control group， while the levels of high density lipoprotein （HDL-C） was higher than that in the control group， and the differences were statistically significant （P<0.05）. The incidence of adverse reactions in the study group was lower than that in the control group， and the difference was statistically significant （P<0.05）. Conclusion： Atorvastatin combined with fast walking exercise can improve the vascular elasticity in patients with carotid atherosclerosis， reduce the plaque area and the number of plaques， reduce blood lipids， and help to reduce the adverse reactions of drugs.

[Key words] Atorvastatin Calcium Tablets Fast walking exercise Carotid atherosclerosis Blood lipid levels

First-authors address： Taishan Peoples Hospital， Taishan 529200， China

颈动脉粥样硬化形成的具体病因并未明确，但血脂异常是导致颈动脉粥样硬化的危险因素，在临床上予以阿托伐他汀钙片治疗，通过降低血脂来延缓斑块的进展，已经取得了不错的临床疗效[1]。但对于已经形成了的斑块数量、斑块面积、血管弹性等的疗效可能具有一定的局限性，单一并且长期服用可能会导致药物的不良反应增多[2]。快步运动可以促进脂质类代谢，引起身体有利的应激性反应，可能会弥补上述单一药物治疗的局限[3]。故本次研究阿托伐他汀联合快步运动对颈动脉粥样硬化患者的治疗效果，现将研究结果报道如下。

1 资料与方法

1.1 一般资料

选取2018年1月-2019年1月笔者所在医院颈动脉粥样硬化患者168例，纳入标准：（1）均通过颈部血管超声检查发现颈部血管粥样硬化;（2）患者曾发作过脑梗死但未引起肢体活动障碍;（3）从未发生脑梗死但经检查发现颈部血管粥样硬化;（4）可以有效正确配合运动。……