胡利芬 周延峰 彭莹洁 梁文涛 韦旭荣

[摘要]目的 探討阴道炎患者采用妇炎平胶囊联合甲硝唑栓治疗对阴道微生态的影响。方法 选取2019年1～6月清溪镇社区卫生服务中心收治的400例阴道炎患者作为研究对象，采用随机数字表法将其分观察组（妇炎平胶囊+甲硝唑栓）与对照组（甲硝唑栓），每组各200例，比较两组患者的阴道微生态指标及治疗效果。结果 治疗后，观察组患者的阴道pH值、阴道菌群密集度及菌群多样性改善程度优于对照组，差异有统计学意义（P<0.05）。观察组患者的乳酸杆菌计数高于对照组，差异有统计学意义（P<0.05）。观察组患者总有效率（95.50%）高于对照组（82.50%），差异有统计学意义（P<0.05）。两组患者不良反应总发生率比较，差异无统计学意义（P>0.05）;随访3个月后观察组复发率（5.24%）低于对照组（27.88%），差异有统计学意义（P<0.05）。结论 妇炎平胶囊联合甲硝唑栓治疗阴道炎能改善阴道内环境，提高疗效，减少不良反应，还能预防疾病复发。

[关键词]阴道炎;妇炎平胶囊;甲硝唑栓;阴道微生态;临床疗效

[中图分类号] R711.31          [文献标识码] A          [文章编号] 1674-4721（2020）7（b）-0125-04

Discuss the clinical effect of Fuyanping Capsules combined with Metronidazole Suppository on vaginitis based on vaginal microecology

HU Li-fen   ZHOU Yan-feng PENG Ying-jie   LIANG Wen-tao   WEI Xu-rong

Community Health Service Center， Qingxi Town， Dongguan City， Guangdong Province， Dongguan   523660， China

[Abstract] Objective To explore the clinical effect of Fuyanping Capsules combined with Metronidazole Suppository on vaginal microecology in patients with vaginitis. Methods From January to December 2019， 400 patients with vaginitis received treatment in the Community Health Service Center of Qingxi Town were randomly divided into the observation group （Fuyanping Capsules with Metronidazole Suppository） and the control group （Metronidazole Suppository， with 200 cases in each group. The vaginal microecological indexes and therapeutic effect of the two groups were compared. Results After treatment， the pH value， bacterial density and diversity of vagina in the observation group were better than those in the control group， the differences were statistically significant （P<0.05）. The number of lactobacilli in the observation group was higher than that in the control group， the difference was statistically significant （P<0.05）. The total effective rate in the observation group （95.50%） was higher than that in the control group （82.50%）， the difference was statistically significant （P<0.05）. There was no statistically significant difference in the total incidence of adverse reactions of patients between the two groups （P>0.05）. After 3 months of follow-up， the relapse rate in the observation group （5.24%） was lower than that in the control group （27.88%）， the difference was statistically significant （P<0.05）. Conclusion Fuyanping Capsules combined with Metronidazole Suppository for vaginitis can improve the internal environment of the vagina， improve the curative effect， reduce adverse reactions， and prevent disease recurrence.

[Key words] Vaginitis; Fuyanping Capsules; Metronidazole Suppository; Vagina microecology; Clinical effect

阴道炎是女性生殖道感染中最常见的疾病，其具有发病率高、病程长、反复发作及迁延难愈等特点，对女性在生活、身体都造成了严重的影响，现已成为女性常见的一个公共卫生问题。目前对阴道炎采用单一的抗菌药物治疗效果并不理想，且复发率高，细菌容易产生耐药性使治疗更加困难。对阴道炎的治疗，其目的主要是控制临床症状，降低复发率，恢复阴道微生态系统及其阴道防御体制[1-2]，因此怎样选用药物达到治疗目的尤为重要;嵇静[3]研究认为，早期提供联合用药治疗能改善预后效果，控制疾病进展，且提高疗效。本研究分析阴道炎患者采用婦炎平胶囊联合甲硝唑栓治疗的临床效果及其对阴道微生态的影响，现报道如下。

1资料与方法