钟蕊　翁志军　赵继梦　李昆珊　吴璐一　黎梅　黄艳　顾沐恩　周志刚　许琼

摘要 检索2010年1月至2020年2月万方数据库（Wangfang Data）、中国期刊全文数据库（CNKI）、维普中文期刊平台（VIP）及Pubmed数据库中，艾灸治疗溃疡性结肠炎（Ulcerative Colitis，UC）临床与实验机制研究文献。以“艾灸”或“灸法”或“moxibustion”“溃疡性结肠炎”或“炎症性肠病”或“ulcerative colitis”为检索词，纳入临床或实验机制研究文献，排除综述类文献、个案、病例报告等，最终筛选出46篇国内外相关文献，以此总结近10年艾灸治疗UC临床及实验机制。从调节患者免疫平衡、调节肠道菌群、改善肠黏膜屏障功能、调节细胞凋亡进行分析综述并对未来研究提出思考与展望。

关键词 溃疡性结肠炎;艾灸;肠黏膜屏障;细胞凋亡;免疫平衡

Research Progress on the Mechanism of Moxibustion in the Treatment of Ulcerative Colitis

ZHONG Rui1，WENG Zhijun2，3，ZHAO Jimeng2，3，LI Kunshan2，WU Luyi2，LI Mei1，HUANG Yan2，3，GU Muen2，ZHOU Zhigang4，XU Qiong1

（1 Shanghai Institute of Qigong，Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China; 2 Key Laboratory of Acupuncture and Immune Effect，Shanghai University of Traditional Chinese Medicine，Shanghai 200030，China; 3 Department of Acupuncture and Immunology，Shanghai Institute of Acupuncture，Moxibustion and Meridian; 4 Jiangxi School of International Education，University of Chinese Medicine，Nanchang 330004，China）

Abstract The author searched clinical and experimental mechanism literatures of moxibustion treatment of ulcerative colitis（UC）in Wangfang Data，China Journal Full-text Database（CNKI），VIP Chinese Journal Platform（VIP）and Pubmed Database from January 2010 to February 2020.“艾灸” or “灸法” or “moxibustion”，“ulcerative colitis” or “inflammatory bowel disease” or “ulcerative colitis” were used as search terms to include clinical or experimental mechanism research literature.Review literatures，cases，case reports etc.，were excluded.Finally 46 domestic and foreign related literatures were selected to summarize the clinical and experimental mechanisms of moxibustion treatment of UC in the past ten years.The author analyzed and reviewed the immune balance of the patients，regulation of intestinal flora，improvement of intestinal mucosal barrier function，and apoptosis regulationes of，and proposed the thinking and prospects for future research.

Keywords Ulcerative colitis; Moxibustion; Intestinal mucosal barrier; Apoptosis; Immune balance

中圖分类号：R245文献标识码：Adoi：10.3969/j.issn.1673-7202.2020.15.031

溃疡性结肠炎（Ulcerative Colitis，UC）是一种累及直肠、结肠黏膜及黏膜下层的慢性非特异性炎症性肠病，临床变现主要为腹痛、腹泻、黏液脓血便等，有时也会出现肠外表现，主要累及关节、肝胆、眼睛、口腔及皮肤[1-2]，发病病情轻重不等，病情多反复发作或长期迁延，病程漫长。随着病情迁延反复，易导致结肠息肉增生，肠腔狭窄，并有可能引起结肠炎相关性癌变[3-4]。全球UC总发病率为1.2～20.3/10万人，患病率为7.6～245/10万人[5]，近年来我国UC的发病率也呈现增高趋势，现已成为消化系统常见疾病，危害国民身体健康。

目前溃疡性结肠炎的发病机制尚未明确，目前的研究主要认为与遗传易感性[6]、外部环境、内部肠道免疫紊乱、肠黏膜屏障损伤等有关[7-8]。中医学无“溃疡性结肠炎”病名，临证多归为“肠风”“肠澼”“久泻”等进行辨证论治。……