闫慧明 安燕 齐革清 刘远 刘咏梅 党彤 石继海 张雪

【摘 要】目的：调查包头地区罹患高尿酸血症患者情况。方法：对内蒙古科技大学包头医学院第二附属医院体检中心的4919例体检人群进行分析，根据尿酸是否增高分为高尿酸血症组和血尿酸正常组，根据性别分为男性组和女性组。结果：包头地区高尿酸血症发病率22.59%，男性发病率15.33%，女性发病率7.23%，男女比为2.1∶1;男性高尿酸血症的患病率在30～49岁最高，女性在50～59岁最高，之后血尿酸呈下降趋势;不同年龄段男女血尿酸水平有差异，相同年龄段男性血尿酸高于女性，仅在80～89岁女性高于男性（P < 0.05）;男性患高尿酸血症时年龄较小，女性患高尿酸血症时年龄较大（P < 0.05）;高尿酸血症患者血肌酐水平较高（P < 0.05）;Logistic回归分析显示，男性患高尿酸血症的风险是女性的6.167倍;三酰甘油是高尿酸血症的保护因素（P < 0.05）。结论：包头地区高尿酸血症发病率较高，年轻男性30～49岁发病率高，女性50岁之后发病率开始升高，同时伴有血肌酐升高，男性患高尿酸血症的风险是女性的6.167倍;三酰甘油是高尿酸血症的保护因素。

【关键词】 高尿酸血症;调查;饮食;发病率

【ABSTRACT】Objective：To investigate the situation of patients with hyperuricemia in Baotou area.Methods：An analysis was made for 491，9 people visiting the Physical Examination Center of the Second Affiliated Hospital of Baotou Medical College，Inner Mongolia University of Science & Technology.According to the increase of uric acid，they were divided into a hyperuricemia group and a normal uric acid group.According to gender，they were divided into a male group and a female group.Results：The incidence rate of hyperuricemia in Baotou area was 22.59%（male 15.33%，female 7.23%），and the ratio of male to female was 2.1∶1.The highest incidence of male was between the age of 30 and 49，and the highest in female was between 50 and 59 years old.Levels of Serum uric acid were different at different ages，but that of male was higher than female in same age group.Between 80 and 89 years old，serum uric acid of female was higher than male（P < 0.05）.Male was younger when suffering from hyperuricemia，while female was older when hyperuricemia appeared（P < 0.05）.The level of serum creatinine in patients with hyperuricemia was higher（P < 0.05）.Logistic regression analysis showed that the risk of hyperuricemia in men was 6.167 times higher than that in women;and triacylglycerol was the protective factor of hyperuricemia（P < 0.05）.Conclusion：Incidence rate of hyperuricemia in Baotou is higher，especially for male between the ages of 30 and 49 and female over 50 years old.At the same time，the serum creatinine is increasing.The risk of hyperuricemia of man is 6.167 times that of female.Triacylglycerol is the protective factor for hyperuricemia.

【Keywords】 hyperuricemia;investig-ation;diet;incidence rate

高尿酸血癥（hyperuricemia，HUA）是指在正常嘌呤饮食状态下，非同日2次空腹血尿酸水平升高。患病率受到多种因素的影响，与遗传、性别、年龄、生活方式、饮食习惯、药物治疗和经济发展程度等有关。根据近年各地HUA患病率的报道，目前我国约有1.8亿HUA患者，约占总人口的15%，高发年龄为中老年男性和绝经后女性，但近年来有年轻化趋势[1]。本研究通过调查包头地区HUA发病情况，以指导临床治疗。

1 资料与方法

1.1 一般资料 选取2019年1月至2019年4月在内蒙古医科大学包头医学院第二附属医院体检中心的体检人群4919例，年龄10～99岁。HUA诊断标准：尿酸水平男性≥417 μmol·L-1（7 mg·dL-1），女性≥357 μmol·L-1（6 mg·dL-1）[2]。本研究通过内蒙古医科大学包头医学院第二附属医院伦理委员会审查。

1.2 研究方法

1.2.1 分組 将4919例体检者根据血尿酸水平分为HUA组和血尿酸正常组，再根据性别分为男性组和女性组。……