丁宁

摘 要 目的：通过分析老年人群血尿酸与血脂水平，探究老年人高尿酸血症与血脂代谢紊乱之间的关系。方法：研究纳入社区9 385名60岁以上老年人，其中男性4 265例，平均年龄（69.52±7.07）岁；女性5 120例，平均年龄（70.00±7.41）岁。通过问卷调查、体格检查与实验室检查获得老年人的健康信息。结果：在9 385名老年人中的高尿酸血症检出率为22.87%。高尿酸血症组老年人的体重指数、高血压患病率、总胆固醇（TC）、三酰甘油（TG）水平均显著高于尿酸正常组。高密度脂蛋白胆固醇（HDL-c）明显低于尿酸正常组。多因素logistic回归分析发现TC和TG是老年人高尿酸血症的风险因素，HDL-c是老年人高尿酸血症的保护因素。结论：老年人群血尿酸水平与血脂水平密切相关，在老年人高尿酸血症的早期筛查与防治中应当同时也重视对于血脂水平的检测。

关键词 血尿酸；血脂；老年人；相关性

中图分类号：R589.7 文献标志码：A 文章编号：1006-1533（2020）10-0051-03

Study of the correlation between hyperuricemia and serum lipids in the elderly population

DING Ning

（General Practice Department of Waigang Community Health Center of Jiading District， Shanghai 201806， China）

ABSTRACT Objective： To explore the relationship between hyperuricemia and dyslipidemia in the elderly by analyzing the levels of serum uric acid and serum lipids in the elderly population. Methods： A total of 9 385 adults over 60 years old were included in the study， and among them there were 4 265 males with the average age of （ 69.52±7.07） years old and 5 120 females with the average age of （ 70.00±7.41） years old. The health information of the elderly was obtained by the questionnaire， physical examination and laboratory examination. Results： The detection rate of hyperuricemia in 9 385 elderly people was 22.87%. The body mass index， prevalence of hypertension， total cholesterol（TC） and triglyceride（TG） levels of the elderly in the hyperuricemia group were significantly higher than those in the normal uric acid group. High density lipoprotein cholesterol（HDL-C） in the hyperuricemia group was significantly lower than that in normal uric acid group. Multivariate logistic regression analysis found that TC and TG were risk factors for hyperuricemia in the elderly， and HDL-C was a protective factor for hyperuricemia in the elderly. Conclusion： The blood uric acid level is closely related to the blood lipid level in the elderly， and in the early screening and prevention of hyperuricemia in the elderly attention should also be paid to the detection of blood lipid level.

KEY WORDS serum uric acid； blood lipid； elderly people； correlation

尿酸（uric acid，UA）作為体内嘌呤代谢的终产物，在正常情况下的生成和排泄处于动态平衡状态，一旦平衡被打破会导致高尿酸血症。血尿酸水平升高是痛风性肾病以及特发性关节炎的重要临床指标[1-2]。流行病学研究证实，近10年我国高尿酸血症患病率由5.46%增长至19.30%，中老年男性和绝经后女性为高发人群[3]。有研究提示，高尿酸血症与高的三酰甘油（TG）和低的高密度脂蛋白胆固醇（HDL-c）相关[4]，而低密度脂蛋白胆固醇（LDL-c）和TG升高被认为是心血管疾病的危险因素。因此，探究老年人群血尿酸水平与血脂水平之间的相关性对于老年人心血管疾病的防控具有重要的临床意义。……