崔锐华

【摘要】 目的：分析阿奇霉素联合孟鲁司特钠（顺尔宁）治疗儿童支原体肺炎的效果及安全性。方法：选择在2016年5月-2018年11月笔者所在医院儿科接收的支原体肺炎患儿86例，以随机方式分为两组，各43例。对照组给予常规阿奇霉素治疗，研究组则是在阿奇霉素基础上实施孟鲁司特钠对患儿进行治疗，对比两组患儿的临床疗效、肺功能改善、不良反应发生情况。结果：研究组患儿的治疗总有效率相比对照组更高，差异有统计学意义（P<0.05）;治疗前两组的FEV1、PEF、FEV1/FVC肺功能水平比较，差异无统计学意义（P>0.05），治疗后研究组患儿FEV1、PEF、FEV1/FVC肺功能水平均高于对照组，差异有统计学意义（P<0.05）;两组患儿均未出现不良反应。结论：临床上使阿奇霉素联合用孟鲁司特钠对儿童支原体肺炎疾病治疗，可改善患儿肺功能、提高治疗效果，无不良反应产生，治疗安全性高。

【关键词】 支原体肺炎; 儿童; 孟鲁司特钠; 阿奇霉素; 疗效; 安全性

doi：10.14033/j.cnki.cfmr.2019.16.053 文献标识码 B 文章编号 1674-6805（2019）16-0-03

【Abstract】 Objective：To analyze the efficacy and safety of Azithromycin combined with Montelukast Sodium（Shunerning）in the treatment of Mycoplasma pneumonia in children.Method：A total of 86 children with Mycoplasma pneumonia received in our hospital from May 2016 to November 2018 were selected and randomly divided into two groups，with 43 cases in each group.The control group was treated with conventional Azithromycin，while the study group was treated with Montelukast Sodium on the basis of Azithromycin.The clinical efficacy，pulmonary function improvement and adverse reactions of the two groups were compared.Result：The total effective rate of the study group was higher than that of the control group，the difference was statistically significant（P<0.05）.There were no difference in FEV1，PEF，FEV1/FVC pulmonary function between the two groups before treatment（P>0.05）.After treatment，the levels of FEV1，PEF，FEV1/FVC pulmonary function of the study group were higher than those of the control group，and the differences were statistically significant（P<0.05）.There were no adverse reactions in both groups.Conclusion：Azithromycin combined with Montelukast Sodium in the treatment of Mycoplasma pneumonia in children can improve pulmonary function and therapeutic effect，without adverse reactions，and has high treatment safety.

【Key words】 Mycoplasma pneumonia; Children; Montelukast Sodium; Azithromycin; Efficacy; Safety

First-authors address：Jingzhou Second Peoples Hospital，Jingzhou 434000，China

支原体肺炎为一种较常见的肺部急性炎症疾病，主要由肺部支原體感染所引致，具有季节性发病特征，多发生于秋、冬季节，患者典型临床症状表现为咽喉疼痛、顽固性剧烈咳嗽、身体乏力、发热、腹痛腹泻、食欲不振等[1-3]，若患者为儿童，能够会伴有中耳炎、鼓膜炎、颈淋巴结肿大等病症。近些年儿童支原体肺炎的发病率呈逐年上升趋势，由于儿童的机体抵抗力较弱，若未得到及时有效治疗可能会诱发继发性哮喘疾病，从而对身体健康、成长发育造成较大影响。孟鲁司特钠具有良好的耐受性，且不会让机体产生不良反应[4]，与阿奇霉素联合应用的治疗效果明显，因此本研究选取在笔者所在医院接受治疗的支原体肺炎患儿，实施孟鲁司特钠联合阿奇霉素治疗，探究其疗效、治疗安全性。……