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不同剂量左甲状腺素治疗老年亚临床甲状腺功能减退症的效果分析

2019-08-19胡显洁

中外医疗 2019年14期
关键词:不同剂量老年

胡显洁

[摘要] 目的 探讨不同剂量左甲状腺素治疗老年亚临床甲状腺功能减退症的效果。方法 方便选取2018年3—12月到该院接受治疗的70例老年亚临床甲状腺功能减退症患者,随机分为对照组35例(低剂量)与观察组35例(高剂量),比较两组血脂水平、甲状腺功能及不良反应发生率指标。 结果 治疗结束,诊治后6周观察组在LDL-C、TG及TC指标上均更低于对照组且差异有统计学意义(P<0.05);诊治后6周观察组在FT4、FT3、TSH指标上均优于对照组且差异有统计学意义(P<0.05);诊治后12周观察组在LDL-C、TG、TC、FT4、FT3及TSH指标上与对照组差异无统计学意义(P>0.05);观察组不良反应发生率(17.14%)显著高于对照组(2.86%)且差异具有统计学意义(P<0.05)。 结论 高剂量方法可有效提升老年亚临床甲状腺功能减退症患者临床疗效,值得推广使用。

[关键词] 亚临床甲状腺功能减退症;不同剂量;左甲状腺素;老年

[中图分类号] R581.2          [文献标识码] A          [文章编号] 1674-0742(2019)05(b)-0097-03

[Abstract] Objective To investigate the effect of different doses of levothyroxine on subclinical hypothyroidism in elderly patients. Methods 70 elderly patients with subclinical hypothyroidism who were treated in our hospital from March to December 2018 were convenient selected and randomly divided into the control group of 35 cases (low dose) and the observation group 35 cases (high dose). The blood lipid levels, thyroid function and incidence of adverse reactions were compared between the two groups. Results At the end of treatment, the LDL-C, TG and TC indexes were significantly lower in the observation group than in the control group at 6 weeks after treatment (P<0.05). The observation group was in FT4, FT3, TSH 6 weeks after diagnosis and treatment. The indexes were superior to the control group and the difference was statistically significant (P<0.05). The 12-week observation group had little difference between the LDL-C, TG, TC, FT4, FT3 and TSH indicators and the control group. The significance of learning (P>0.05); the incidence of adverse reactions in the observation group (17.14%) was significantly higher than the control group (2.86%) and the difference was statistically significant (P<0.05). Conclusion The high-dose method can effectively improve the clinical efficacy of elderly patients with subclinical hypothyroidism, which is worthy of popularization.

[Key words] Subclinical hypothyroidism; Different doses; Levothyroxine; Old age

甲狀腺功能减退症是一种病发率较高的代谢异常性临床常见病,早期治疗不及时易致使患者生存质量不佳,引起较多的并发症疾病[1]。近几年临床治疗甲状腺功能减退症多采用左甲状腺素药物方法作相应诊治,为改善患者临床病症,该文方便选取2018年3—12月70例患者探讨了不同剂量该药物在甲状腺功能减退症疾病中的效果,现报道如下。

1  资料与方法

1.1  一般资料

方便选取该院收治的老年亚临床甲状腺功能减退症患者,总计70例,随机分为两组,采用高剂量方法的一组(35例)作为观察组,使用低剂量方法的一组(35例)作为对照组。性别:观察组女19例,男16例,对照组女20例,男15例;年龄:观察组61~86岁,平均为(68.92±7.16)岁,对照组63~87岁,平均为(69.24±7.52)岁。比较以上一般资料,差异无统计学意义(P>0.05)。纳入标准:①70例患者据临床病理学诊断,均符合亚临床甲状腺功能减退症病况。②年龄≥60岁者。③70例患者自愿签署知情同意书。排除标准:①该次研究药物使用禁忌者。②严重癫痫、脑器质性疾病或心理障碍者。③中途退出研究者。

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