李庆娓

[摘要] 目的 探究阿奇霉素联合红霉素对小儿支原体肺炎的治疗效果，为临床推广提供重要的参考依据。 方法 方便选取该院2017年3月—2018年3月呼吸内科小儿支原体肺炎患者142例为研究对象。随机将患者分为对照组和观察组，每组71例。其中对照组小儿支原体肺炎患者通过紅霉素进行治疗，观察组患者通过阿奇霉素与红霉素联合进行治疗，对两组患者的治疗效果进行对比分析。 结果 观察组进行阿奇霉素与红霉素联合治疗，可以有效提高治疗效果，观察组患者的痊愈率为92.96%，远远高于对照组的76.06%，两组差异有统计学意义（χ2=11.785 1，P=0.005）;观察组患者退热时间（1.86±0.71）d和止咳时间（2.45±1.46）d，而对照组患者退热时间（4.59±1.51）d和止咳时间（6.29±1.87）d，组间差异有统计学意义（χ2=11.263 9，P=0.012）。另外观察组的不良反应发生率仅为26.76%，远低于对照组的64.79%，对照组和实验组的数据差异有统计学意义（χ2=12.304 9，P=0.003）。结果 通过对小儿支原体肺炎患者进行阿奇霉素联合红霉素治疗，不仅可以缩短痊愈的时间，而且可以减轻患者治疗过程中的痛苦，对小儿支原体肺炎的治疗具有重要意义。

[关键词] 阿奇霉素;红霉素;支原体肺炎;止咳

[中图分类号] R563          [文献标识码] A          [文章编号] 1674-0742（2018）08（c）-0113-03

Analysis of Efficacy of Azithromycin Combined with Erythromycin in the Treatment of Mycoplasma Pneumonia in Children

LI Qing-wei

Department of Pediatrics， Shihezi Textile Hospital， Xinjiang Uygur Autonomous Region， Shihezi， Xinjiang， 832004 China

[Abstract] Objective To investigate the effect of azithromycin combined with erythromycin in the treatment of mycoplasma pneumonia in children and provide an important reference for clinical promotion. Methods A total of 142 patients with mycoplasma pneumonia in the Department of Respiratory Medicine from March 2017 to March 2018 in the hospital were convenient selected as study subjects. Patients were randomly divided into control and observation groups， with 71 cases in each group. In the control group， patients with mycoplasma pneumonia were treated with erythromycin， and patients in the observation group were treated with azithromycin and erythromycin. The therapeutic effects of the two groups were compared. Results The combined treatment of azithromycin and erythromycin in the observation group could effectively improve the therapeutic effect. The cure rate of the observation group was 92.96%， which was much higher than that of the control group（76.06%）. the two groups had statistical significance（χ2=11.785 1， P=0.00 5）; In the observation group， the time of fever （1.86±0.71）d and cough time （2.45±1.46）d were observed in the observation group， while the time of antipyretic treatment （4.59±1.51）d and cough retting （6.29±1.87）d in the control group. Differences between groups were statistically significant（χ2=11.263 9， P=0.012）. In addition， the incidence of adverse reactions in the observation group was only 26.76%， which was far lower than the 64.79% in the control group. The difference between the control group and the experimental group was statistically significant（χ2=12.304 9， P=0.00 3）. Conclusion The treatment of azithromycin combined with erythromycin in patients with mycoplasma pneumonia in children can not only shorten the recovery time， but also reduce the pain during treatment. It is of great significance for the treatment of mycoplasma pneumonia in children.

[Key words] Azithromycin; Erythromycin; Mycoplasma pneumonia; Cough relieving

支原体肺炎是由肺炎支原体引发的一种多发性疾病，该病的患病群体多为7岁以下的儿童，近年正逐渐趋于低龄化，该病的临床症状为咳嗽、发热、肺部湿啰音等，不但会引发肺部炎症还会造成其它器官的病变，严重威胁着患儿的健康。目前对于小儿支原体肺炎的治疗方法主要为红霉素治疗，随着大环内酯类抗生素的广泛应用，阿奇霉素也逐渐成为该病的治疗药物，为了综合二者的优势，该院对阿奇霉素联合红霉素来治疗小儿支原体肺炎展开了研究，并取得了显著的疗效。……