冯徐俊　付云杰

[摘要] 目的 分析老年肺炎患者進行氨溴索联合莫西沙星治疗的临床疗效。 方法 随机选取2015年12月～2017年12月本院收治的52例老年肺炎患者，以随机数字表法分为试验组与对照组，各26例。对照组采用氨溴索治疗，试验组在对照组基础上，联合氨溴索联合莫西沙星治疗。比较两组炎性指标、动脉血气指标、治疗效果、住院情况。 结果 与对照组治疗后TNF-α、hs-CRP、IL-8、IL-6、PaCO2、PEEPi指标比较，试验组较低，与对照组治疗后PaO2、PEF指标比较，试验组较高，差异有统计学意义（P<0.05）；与对照组临床总有效率（65.38%）比较，试验组（95.15%）较高，与对照组住院时间比较，试验组较短，差异有统计学意义（P<0.05）；与对照组住院费用比较，试验组较低，差异有统计学意义（P<0.05）。 结论 氨溴索联合莫西沙星可有效减轻老年重症肺炎患者的炎性症状，改善肺通气，加快机体恢复，效果确切，值得临床推广应用。

[关键词] 老年肺炎；氨溴索；莫西沙星

[中图分类号] R563.1 [文献标识码] B [文章编号] 1673-9701（2018）20-0053-04

Clinical analysis of ambroxol combined with moxifloxacin in treatment of Pneumonia in elderly patients

FENG Xujun FU Yunjie

Department of Respiratory Medicine， Jiujiang First People's Hospital in Jiangxi Province， Jiujiang 332000， China

[Abstract] Objective To analyze the clinical efficacy of ambroxol combined with moxifloxacin in from the elderly patients with pneumonia. Methods 52 elderly patients with pneumonia who were admitted to our hospital December 2015 to December 2017 were randomLy selected. They were grouped based on the random number table method， and were divided into experimental group and control group， with 26 patients in each group. The control group was given ambroxol for treatment， and the experimental group was given ambroxol combined with moxifloxacin on the basis of the control group. The inflammatory index， arterial blood gas index， therapeutic effect， and hospitalization were compared. Results Compared with the control group， the TNF-α， hs-CRP， IL-8， IL-6， PaCO2， and PEEPi indices were lower in the experimental group. Compared with the PaO2 and PEF indices after treatment in the control group，the experimental group was higher， and the differences were statistically significant（P<0.05）； compared with the total clinical effective rate （65.38%） in the control group， experimental group was higher（95.15%）； compared with the length of hospital stay in the control group， the experimental group was shorter， and the difference was statistically significant（P<0.05）； compared with the hospitalization cost in the control group， the experimental group was lower， and the difference was statistically significant（P<0.05）. Conclusion Ambroxol combined with moxifloxacin can effectively reduce the inflammatory symptoms of elderly patients with severe pneumonia， improve lung ventilation， and accelerate the recovery of the body. The effect is definite and the method is worthy of being learned from.

[Key words] Elderly pneumonia； Ambroxol； Moxifloxacin

肺炎是一种临床常见病，多见于老年患者，具有较高的致死率，由于老年患者机体耐受力、体质、抗感染功能均有所下降，全身炎症反应会进一步加重，极易引发多器官功能衰竭，因此及早的控制感染对于提高患者救治成功率具有一定的积极意义，氨溴索是目前临床治疗该病的常用药，但是单纯氨溴索治疗，无法有效控制机体炎症，具有一定的局限性[1-2]。在上述研究背景下，本文为了分析老年肺炎患者进行氨溴索联合莫西沙星治疗的临床疗效，特随机选定2015年12月～2017年12月本院收治的52例老年肺炎患者进行分析，现报道如下。

1 资料与方法

1.1 一般资料

随机选定本院收治的52例老年肺炎患者，2015年12月～2017年12月为研究时段，以随机数字表法分试验组与对照组，各26例。试验组中女12例，男14例，年龄62～80岁，平均（71.6±6.9）岁，病程12～15 d，平均（13.5±2.8）d；体质量18～25 kg/m2，平均（21.9±1.2）kg/m2。对照组中女13例，男13例，年龄64～79岁，平均（71.2±7.1）岁，病程13～17 d，平均（15.1±1.9）d；……