王俊凤　莫洁平　杨志

【摘要】 目的：探討双C疗法治疗 高龄孕妇妊娠期糖尿病（gestational diabetes mellitus，GDM）并妊娠期高血压疾病的可行性。方法：选取2016年1月-2017年12月本院收治的GDM并妊娠期高血压疾病的高龄孕妇140例。根据随机数字表法将其分为观察组和对照组，各70例。对照组给予常规治疗，观察组给予双C疗法。比较两组孕妇治疗前后的血糖（FBG、2 h PG、HbA1c）、血压（SBP、DBP）、肾功能（CysC、RBP），新生儿FBG、1 h血糖（1 h PG），不良情况和血糖达标时间。结果：治疗后，观察组孕妇FBG、2 h PG、HbA1c、SBP、DBP、CysC、RBP均低于对照组，比较差异均有统计学意义（P<0.05）；观察组新生儿FBG、1 h PG水平均低于对照组，比较差异均有统计学意义（P<0.05）；观察组低血糖（孕妇及新生儿）和孕妇黎明现象的发生率、血糖达标时间均低于对照组，比较差异均有统计学意义（P<0.05）。结论：相较于常规疗法，双C疗法治疗高龄孕妇GDM并妊娠期高血压疾病的效果更为显著，可有效改善孕妇和新生儿的血糖、血压水平和肾功能，在降低低血糖和黎明现象的发生率等方面均表现出显著优势，因而值得在临床上进行推广应用。

【关键词】 双C疗法； 高龄孕妇； 妊娠期糖尿病； 妊娠期高血压疾病

Feasibility Analysis of Double C Therapy for Gestational Diabetes Mellitus and Hypertensive Disorder Complicating Pregnancy in Elderly Pregnant Women/WANG Junfeng，MO Jieping，YANG Zhi，et al.//Medical Innovation of China，2018，15（14）：137-140

【Abstract】 Objective：To investigate the feasibility of double C therapy for gestational diabetes mellitus（GDM） and hypertensive disorder complicating pregnancy in elderly pregnant women.Method：A total of 140 elderly pregnant women with GDM and hypertensive disorder complicating pregnancy admitted to our hospital from January 2016 to December 2017 were selected.According to the random number method，they were divided into observation group and control group，70 cases in each group.The control group was given conventional treatment，and observation group was given double C therapy.The blood glucose（FBG，2 h PG，HbA1c），blood pressure（SBP，DBP），renal function（CysC，RBP） before and after treatment in pregnant women，FBG and 1 h plasma glucose（1 h PG） in neonatus，bad condition and blood glucose standard time between two groups were compared.Result：After treatment，the levels of FBG，2 h PG，HbA1c，SBP，DBP，CysC and RBP in observation group were lower than those of control group，the differences were statistically significant（P<0.05）.The FBG and 1 h PG of neonates in observation group were lower than those of control group，the differences were statistically significant（P<0.05）.The incidence of hypoglycemia（pregnant women and neonatus） and pregnant womens dawn phenomenon and blood glucose standard time in observation group were lower than those of control group，the differences was statistically significant（P<0.05）.Conclusion：Compared with conventional therapy，double C therapy is more effective in the treatment of GDM and hypertensive disorder complicating pregnancy in elderly pregnant women，can effectively improve maternal and neonatal blood glucose levels，blood pressure levels and renal function，has obvious advantages in reducing the incidence of hypoglycemia and dawn phenomenon，and is worthy of clinical application.

【Key words】 Double C therapy； Elderly pregnant women； Gestational diabetes mellitus； Hypertensive disorder complicating pregnancy

First-authors address：Duanzhou District MCH in Zhaoqing City，Zhaoqing 526040，China

doi：10.3969/j.issn.1674-4985.2018.14.034

妊娠期糖尿病（gestational diabetes mellitus，GDM）是产科常见的妊娠期并发症，近年来女性由于逐渐将重心转移至教育和工作上，生育的年龄越来越晚，高龄孕妇的人数呈现不断上升趋势[1]，导致GDM的发病率也不断增加，严重影响孕产妇和新生儿的身体健康。若GDM孕妇未能得到及时有效的治疗，就会导致不良分娩结局、妊娠期高血压疾病等并发症的发生[2]，对于产妇和新生儿的健康和安全都会造成直接威胁。GDM多会合并存在妊娠期高血压疾病，对于该病症的治疗，重点在于稳定控制孕妇的血糖和血压水平[3]。双C疗法是强化治疗糖尿病的一种新型技术，将动态血糖监测系统（CGMS）和胰岛素泵（CSII）两者联合，实现对于产妇的个性化血糖控制，并保持对血糖水平的动态监测。本次研究旨在探讨双C疗法治疗高龄孕妇GDM并妊娠期高血压疾病的可行性，现报道如下。

1 资料与方法

1.1 一般资料 选取2016年1月-2017年12月本院收治的GDM并妊娠期高血压疾病的高龄孕妇140例，均在本院经过控制饮食和运动后血糖控制不理想，接受胰岛素治疗。……