刘莉　吴敏　王静

【摘要】 目的：研究替硝唑与盐酸左氧氟沙星联合治疗慢性盆腔炎的临床效果和不良反应。方法：选取2015年7月-2016年7月本院收治的60例慢性盆腔炎患者为研究对象，按照随机数字表法分为对照组与观察组，各30例。对照组给予盐酸左氧氟沙星的单独治疗，研究组在对照组基础上联合使用替硝唑。比较两组临床治疗效果及不良反应发生情况。结果：研究组临床治疗总有效率为93.3%，明显高于对照组的73.3%，差异有统计学意义（字2=4.320 0，P=0.037 6）。研究组不良反应发生率为6.7%，明显低于对照组的26.7%，差异有统计学意义（字2=4.320 0，P=0.037 6）。结论：临床治疗慢性盆腔炎患者时，采用替硝唑与盐酸左氧氟沙星联合用药，其治疗效果明显，不良反应发生率低，具有临床推广价值。

【关键词】 替硝唑； 盐酸左氧氟沙星； 联合用药； 慢性盆腔炎

Clinical Effect Observation of Tinidazole Combine with Levofloxacin Hydrochloride in Treatment of Chronic Pelvic Inflammatory Disease/LIU Li，WU Min，WANG Jing.//Medical Innovation of China，2018，15（14）：134-137

【Abstract】 Objective：To observe the clinical effects and adverse reaction of Tinidazole combine with Levofloxacin Hydrochloride in the treatment of chronic pelvic inflammatory disease.Method：A total of 60 cases with chronic pelvic inflammatory disease in our hospital from July 2015 to July 2016 were divided into control group and study group according to table of random numbers，30 cases in each group.The control group was treated with Levofloxacin Hydrochloride，and the study group was treated with Tinidazole on basis of the control group.The clinical effects and adverse reaction were compared between the two groups.Result：After treatment，the total effective rate in the study group was 93.3%，which was significantly higher than 73.3% in the control group，the difference was statistically significant（字2=4.320 0，P=0.037 6）.The adverse reaction in the study group was 6.7%，which was significantly lower than 26.7% in the control group，the difference was statistically significant（字2=4.320 0，P=0.037 6）.Conclusion：The treatment of Tinidazole combine with Levofloxacin Hydrochloride in chronic pelvic inflammatory disease has obvious effect and low incidence of adverse reactions，it is worthy of promoting in the clinic.

【Key words】 Tinidazole； Levofloxacin Hydrochloride； Drug combination； Chronic pelvic inflammatory disease

First-authors address：Affiliated TCM Hospital of Southwest Medical University，Luzhou 646000，China

doi：10.3969/j.issn.1674-4985.2018.14.033

慢性盆腔炎（chronic pelvic inflammatory disease）是女性疾病中的常見病，其炎症主要集中在女性生殖器及其结缔组织，或发生于盆腹腔中，临床表现为下腹或腰骶部的坠痛、酸痛，严重可导致不孕、异位妊娠等，对患者的生活质量造成影响[1-2]。目前，治疗慢性盆腔炎的方法有很多，由于病症主要为感染，大多采用抗生素进行治疗，但此类病症易反复发作，疗程较长，采用单一药物治疗的效果欠佳，本研究对慢性盆腔炎的临床治疗方式进行了考察，选取2015年7月-2016年7月本院收治的60例慢性盆腔炎患者为研究对象，按照随机数字表法分为对照组与观察组，对照组单独使用盐酸左氧氟沙星，研究组联合使用替硝唑与盐酸左氧氟沙星，分别治疗后比较两组患者的临床治疗效果及不良反应发生情况，现报道如下。……