李佳楠

[摘要] 目的 探讨布拉氏酵母菌散联合左氧氟沙星治疗急性细菌性痢疾的临床效果。 方法 选取本院2017年1～12月收治的150例急性细菌性痢疾患者，采用数字表法随机分为观察组与对照组，每组75例，观察组采用布拉氏酵母菌散联合左氧氟沙星治疗，对照组患者采用左氧氟沙星治疗，比较两组的临床治疗效果及发热、腹痛腹泻消失时间及副作用。 结果 观察组患者治疗后痊愈63例，显效10例，总有效率97.3%，较对照组的80.0%更高，而观察组患者发热、腹痛腹泻临床症状消失时间明显短于对照组。两组副作用均较少。 结论 针对急性细菌性痢疾患者，临床采用布拉氏酵母菌散联合左氧氟沙星治疗安全可靠，临床效果较好，副作用少，具有较高的临床应用价值。

[关键词] 布拉氏酵母菌散；左氧氟沙星；急性细菌性痢疾；副作用

[中图分类号] R442.2 [文献标识码] B [文章编号] 1673-9701（2018）10-0095-03

Clinical effectiveness of saccharomyces Boulardii combined levofloxacin in treatment of patients with acute bacillary dysentery

LI Jia'nan

Jiamusi Hospital of Infectious Disease in Heilongjiang Province， Jiamusi 154007， China

[Abstract] Objective To investigate the clinical effectiveness of saccharomyces boulardii combined levofloxacin in treatment of patients with acute bacillary dysentery. Methods 150 patients with acute bacillary dysentery in our hospital in 2017 were enrolled and randomized into observation group and control group with 75 patients in each by using number table. Patients in observation group were treated with saccharomyces boulardii and levofloxacin while patients in control group were treated with levofloxacin only. The clinical effectiveness， the time of fever， abdominal pain and diarrhea disappeared and the adverse effects occurred in two groups were compared. Results 63 patients recovered and 10 patients were noted remarkable effectiveness in observation group and the total rate of effectiveness was 97.3%， which was significantly higher than that in control group（80.0%） （P<0.05）. The time of fever， abdominal pain and diarrhea disappeared in observation group were shorter than that in control group， which suggested a more rapid onset of effectiveness（P<0.05）. Few adverse effects were found in both of two treatments. Conclusion Treatment combined saccharomyces boulardii and levofloxacin in patients with acute bacillary dysentery was safe and with good clinical effectiveness， few adverse effect and high clinical value.

[Key words] Saccharomyces boulardii； Levofloxacin； Acute bacillary dysentery； Clinical effectiveness； Adverse effect

臨床上，急性细菌性痢疾是由于患者的肠道受到痢疾杆菌感染而引发的传染性肠道疾病，通常情况下急性细菌性痢疾的临床症状危急且严重，如果没能得到及时治疗很有可能会发展成为中毒性痢疾，对患者的生命安全产生威胁[1-2]。这种疾病具有一定的季节性特点，集中患发于夏秋季节，临床研究显示与季节的气候具有相关性，利于痢疾细菌的生长和繁殖[3]。患者一旦发病，临床表现包括突发性的腹痛、腹泻以及黏液脓血便，严重者还会伴随发热及全身性毒血症状及休克[4]。近年来由于受到抗生素使用不规范的影响，痢疾杆菌耐药性增强，给此种疾病的治疗带来一定麻烦，因此旨在观察适合有效的治疗手段为当前临床工作重点[5-6]。……