刘晓春

[摘要] 目的 探讨不同剂量辛伐他汀治疗脑梗死的临床效果。 方法 抽取至我院就诊的脑梗死患者106例（2016.7.12～2017.7.12）作为本次的研究对象，依照随机数字表法进行分组，每组均53例，对两组患者分别采取不同剂量的辛伐他汀治疗，对比两组的治疗效果。 结果 治疗前两组的NFDS评分无明显差异（P>0.05），治疗后实验组的NFDS评分相比常规组明显较低（P<0.05）；实验组与常规组的治疗总有效率分别为92.45%与77.36%，组间比较数据差异显著（P<0.05）；实验组与常规组的不良反应发生率分别为7.55%与5.66%，组间比较数据无明显差异（P>0.05）。 结论 对脑梗死患者采取较大剂量的辛伐他汀治疗可降低神经功能的受损程度，使得治疗效果提高，药物安全有效，值得采纳。

[关键词] 剂量；辛伐他汀；脑梗死

[中图分类号] R743.33 [文献标识码] B [文章编号] 1673-9701（2018）10-0098-03

Clinical effects of different doses of simvastatin in the treatment of cerebral infarction

LIU Xiaochun

Experiment Center， Zaozhuang Vocational College Medical School， Zaozhuang 277000， China

[Abstract] Objective To investigate the clinical effects of different doses of simvastatin in the treatment of cerebral infarction. Methods 106 patients with cerebral infarction who were admitted to our hospital were selected from 2016.7.12 to 2017.7.12 as the study subjects. According to the random number table method， the patients were divided into groups， with 53 patients in each group. Two groups of patients were given different doses of simvastatin for treatment. The treatment effect was compared between the two groups. Results There was no significant difference in NFDS score between the two groups before treatment（P>0.05）. After treatment， NFDS score in the experimental group was significantly lower than that in the conventional group（P<0.05）； the total effective rates in the experimental group and the conventional group were 92.45% and 77.36% respectively after treatment， with significant difference between the two groups（P<0.05）； the incidence rates of adverse reactions in the experimental group and the conventional group were 7.55% and 5.66% respectively， and there was no significant difference between the two groups（P>0.05）. Conclusion The higher dose of simvastatin in the patients with cerebral infarction can reduce the damage of neurological function and improve the treatment effect， which is safe and effective， and is worthy of being adopted.

[Key words] Doses； Simvastatin； Cerebral infarction

腦梗死在临床上较为多见，具有发病率、病死率、复发率均较高的特征[1]，通常选择脑灌注神经细胞抗凝等措施进行治疗，可达到较为显著的治疗效果，随着近些年来医学技术的发展进步，许多学者研究指出[2，3]，降脂药物对于脑梗死患者的疾病治疗意义重大。辛伐他汀属于一类降脂药物，关于其具体的使用剂量与安全性临床上较为关注，本文对其治疗脑梗死的临床疗效进行分析，现报道如下。

1 资料与方法

1.1 一般资料

选取至我院就诊的脑梗死患者106例（2016.7.12～2017.7.12）作为本次的研究对象。纳入标准：经过头颅CT/MRI诊断后明确为脑梗死，满足脑血管病的诊断标准，所有患者均未出现全身并发症，所有患者对本次研究均知情同意。排除标准：将脑部伴有器质性病变，同时其功能性器官的功能不够完善，可能伴有恶性肿瘤、痴呆、蛛网膜下腔出血、凝血功能降低等病变患者排除。