急性胰腺炎患者血浆D—二聚体变化与病情严重程度的相关分析
2018-03-31薛晓培
薛晓培



[摘要] 目的 对急性胰腺炎患者病情严重程度与D-D(血浆D-二聚体)变化的关系进行探讨。方法 方便选取2014年1月—2017年7月入院的120例急性胰腺炎患者,根据依据病情严重程度62例轻度者为轻症组,58例为重度者为重症组,给予D-D检测,分析D-D水平变化情况。结果 重症组入院时D-D(1.31±0.27)μg/mL,入院3d(1.65±0.46)μg/mL,入院7 d(1.86±0.17)μg/mL高于轻症组(P<0.05);轻症组白细胞计数(11.69±3.42)×109/L,PT(12.87±1.58)s,APTT(33.89±2.93)s,BG(6.72±1.55)mmol/L,PCV(0.29±0.01),血鈣(2.35±0.19)g/L优于重症组(P<0.05)。结论 急性胰腺炎患者病情越严重,则各系统的受累越明显,D-D越高。
[关键词] 急性胰腺炎;血浆D-二聚体;病情严重程度;相关性
[中图分类号] R576 [文献标识码] A [文章编号] 1674-0742(2018)01(a)-0043-03
Correlation Analysis of Plasma D-dimer and Severity of Illness in Patients with Acute Pancreatitis
XUE Xiao-pei
Department of Digestive Internal Medicine, Rugao Hospital of TCM, Rugao, Jiangsu Province, 226500 China
[Abstract] Objective This paper tries to investigate the relationship between the severity of acute pancreatitis and D-D (plasma D-dimer). Methods From January 2014 to July 2017, 120 patients with acute pancreatitis admitted to hospital were convenient selected in this study. According to the severity of the disease, 62 mild cases were considered as mild cases group and 58 cases were severe cases as severe cases group. D-D tests were given, DD changes were analyzed. Results In the severe group, D-D (1.31±0.27)μg/mL, 3 days (1.65±0.46)μg/mL, 7 days (1.86±0.17)μg/mL, higher than mild group(P<0.05); hemameba in the mild group was (11.69±3.42)×109/L, PT (12.87±1.58) s, APTT (33.89±2.93)s, BG (6.72±1.55)mmol/L, PCV (0.29±0.01), serum calcium (2.35±0.19)g/L, superior to the severe group (P<0.05). Conclusion Patients with acute pancreatitis, the more serious the disease, the more obvious the involvement of the system, the higher the D-D.
[Key words] Acute pancreatitis; Plasma D-dimer; Severity of the disease; Correlation
急性胰腺炎(以下简称为AP)是一种全身炎症反应的综合征,主要特征是胰腺出现炎性反应,可对多个器官造成累及[1]。依据病情严重程度SAP可分为重症与轻症两种,两种AP临床处理、预后有较大差异,需展开不同救治。AP的发生主要由胰酶被激活导致,胰腺被激活、释放后,可使激肽、毒性物质被释放,使微血管、凝血机制被破坏,导致循环系统有高凝、激发性纤溶亢进[2]。而在高凝状态、激发性纤溶亢进中,D-D是主要分子标志物的一种[3]。近年来,此指标也被应用到了AP的诊断、预后判定中,为对AP患者病情严重程度与D-D的关联性展开探讨,该次研究对2014年1月—2017年7月入院的58例重症ASP、62例轻症SAP患者的D-D检测结果进行如下对照分析,现报道如下。
1 资料与方法
1.1 一般资料
该次研究方便选取该院的120例AP患者为对象,依据病情,行如下分组:轻症组(62例),男34例(54.84%),女28例(45.16%),25~89岁,均值(57.2±7.8)岁;重症组(58例),男32例(55.17%),女26例(44.83%),25~89岁,均值(57.4±7.6)岁。120例患者AP均在多项临床检查下明确确诊,已将有其他血液系统疾病、其他器官严重疾病合并等患者排除。客观对比两组上述资料,差异无统计学意义(P>0.05),能相互对比。……
