钱文慧

[摘要]目的 探讨盐酸米诺环素辅助牙周基础治疗对侵袭性牙周炎患者临床疗效的影响。方法 选取本院2016年11月～2017年11月收治的64例患有侵袭性牙周炎患者，按随机分配的原则分为对照组和观察组，每组32例。对照组给予牙周基础治疗，观察组给予盐酸米诺环素辅助牙周基础治疗。比较两组的临床效果及治疗过程中的不良反应发生情况。结果 观察组的总有效率（90.63%）明显高于对照组（68.76%）（P<0.05）。与治疗前比较，两组治疗后的探诊出血指数（BI）、牙周探诊深度（PD）、附着水平（AL）水平均明显降低，且观察组上述指标的降低幅度显著大于对照组（P<0.05）。两组的不良反总应发生率比较，差异无统计学意义（P>0.05）。结论 盐酸米诺环素辅助牙周炎基础治疗侵袭性牙周炎的临床效果显著，无明显不良反应，安全性好，值得临床推广。

[关键词]盐酸米诺环素；侵袭性牙周炎；基础治疗；临床疗效

[中图分类号] R781.4+2 [文献标识码] A [文章编号] 1674-4721（2018）12（b）-0113-03

[Abstract] Objective To investigate the effect of Minocycline Hydrochloride assisting periodental basic treatment on the clinical curative effect of patients with aggressive periodontitis. Methods All of 64 patients with aggressive periodontitis admitted into our hospital from November 2016 to November 2017 were selected and they were divided into the control group and the observation group according to the principle of random distribution， and each group had 32 cases. The control group was treated with periodontal basic therapy， while the observation group was given Minocycline Hydrochloride assisting periodental non-surgical treatment. The clinical effect and the incidence of adverse reactions during treatment between the two groups were compared. Results The total effective rate of the observation group （90.63%） was significantly higher than that of the control group （68.76%） （P<0.05）. Compared with those before treatment， the level of bleeding index （BI）， the depth of periodontal detection （PD） and the level of attachment （AL） of the two groups significantly decreased after tretment， and the decrease in the observation group was significantly greater than that of the control group （P<0.05）. The reduction of the above indexes in the observation group was significantly larger than that in the control group （P<0.05）. There was no significant difference in the total incidence of adverse reactions between the two groups （P<0.05）. Conclusion Clinical effect of Minocycline Hydrochloride assisting periodental basic treatment treating aggressive periodontitis is significant， and has no obvious adverse reactions and high safety. It is worthy of clinical promotion.

[Key words] Minocycline Hydrochloride； Aggressive periodontitis； Basic treatment； Clinical curative effect

侵襲性牙周炎是在临床表现、实验室检查均与慢性牙周炎有明显区别的一种牙周炎，是一种有家族聚集牙周炎的疾病，也是临床口腔常见疾病之一[1]。引起侵袭性牙周炎的主要原因是牙菌斑中特定微生物伴放线菌的感染和宿主本身情况而引起感染，该病发病较早且危害严重，可快速侵犯牙龈、牙周膜、牙槽骨、牙骨质，是造成我国成年人牙齿缺失的主要原因，对患者的生活质量及形象美观造成严重影响[2]。侵袭性牙周炎的病因复杂，早诊断、早治疗是治疗该病的关键，彻底消除感染，保持口腔内牙周组织清洁。根据治疗方式的不同，牙周基础治疗可以分为龈上洁治和龈下刮治两种手术方法，另外还包括患牙（无法保留）拔除、咬合关系调整以及牙周袋处理等。……