张晓霞

[摘要]目的 探讨长春西汀联合疏血通治疗急性脑梗死的临床疗效。方法 选取2015年1月～2016年1月我院收治的86例急性脑梗死患者作为研究对象，根据治疗方法的不同，将其分为研究组和对照组，每组各43例。两组患者均予以吸氧、维持生命体征平稳、肠溶阿司匹林口服、静脉输入脑细胞营养剂、降血脂药物等对症支持治疗，观察组予长春西汀20 mg加入0.9%氯化钠注射液250 ml静脉滴注，1次/d，疏血通6 ml加入5%葡萄糖注射液250 ml静脉滴注，1次/d，疗程14 d；对照组予胞二磷胆碱0.75 g加入0.9%氯化钠注射液250 ml静脉滴注，复方丹参注射液20 ml加入5%葡萄糖注射液250 ml静脉滴注，1次/d，疗程14 d。比较两组患者的临床疗效及治疗前后NIHSS、ADL评分变化。结果 治疗后，研究组患者的总有效率（97.6%）明显高于对照组（76.7%），差异有统计学意义（P<0.05）；治疗前，两组患者的NIHSS、ADL評分比较，差异均无统计学意义（P>0.05）；治疗后，研究组患者的ADL评分明显高于对照组，NIHSS评分明显低于对照组，差异有统计学意义（P<0.05）。结论 长春西汀联合疏血通治疗急性脑梗死，疗效显著，能够明显改善患者的神经功能，提高患者的生活质量，值得在临床中广泛推广和应用。

[关键词]急性脑梗死；长春西汀；疏血通；临床疗效；神经功能

[中图分类号] R743.33 [文献标识码] A [文章编号] 1674-4721（2017）09（a）-0119-03

The clinical curative effect of Vinpocetine combined with Shuxuetong Injection in treatment of acute cerebral infarction

ZHANG Xiao-xia

Department of Neurology，Pulandian Central Hospital，Liaoning Province，Dalian 116200，China

[Abstract]Objective To investigate the clinical effect of Vinpocetine combined with Shuxuetong Injection in treatment of acute cerebral infarction.Methods 86 cases of patients with acute cerebral infarction admitted in our hospital from January 2015 to January 2016 were selected as the study subjects.They were divided into study group and control group according to different treatment methods，each group of 43 cases.The patients in two groups were treated with oxygen inhalation，maintenance of vital signs，Aspirin oral，intravenous input of brain cell nutrition，blood lipid-lowering drug and other symptomatic and supportive treatment.The patients in the study group were given Vinpocetine 20 mg joined in 0.9% Sodium Chloride Injection 250 ml intravenous drip，1 time a day，Shuxuetong Injection 6 ml joined in 5% Glucose Injection 250 ml intravenous drip，1 time a day，the course of treatment was 14 days.The patients in the control group were treated with Citicoline 0.75 g joined in 0.9% Sodium Chloride Injection 250 ml intravenous drip，Fufang Danshen injection 20 ml joined in 5% Glucose Injection 250 ml intravenous drip，1 time a day，the course of treatment was 14 days.The clinical efficacy of the two groups were compared，the changes of NIHSS and ADL scores before and after treatment in the two groups were also compared.Results After treatment，the total effective rate of patients in the study group （97.6%） was higher than that in the control group （76.7%），and the difference was statistically significant （P<0.05）.NIHSS and ADL scores were compared in the two groups before treatment，and the differences were not statistically significant （P>0.05）.After treatment，the ADL score of the patients in the study group was significantly higher than that in the control group，the NIHSS score was significantly lower than that in the control group，and the differences were statistically significant （P<0.05）.Conclusion Vinpocetine combined with Shuxuetong Injection in the treatment of acute cerebral infarction can significantly improve the neurological function and the life quality of patients.It is worthy of clinical popularization and application.endprint

[Key words]Acute cerebral infarction；Vinpocetine；Shuxuetong Injection；Clinical curative effect；Nerve function

急性脑梗死是神经内科的常见病和多发病，随着目前我国人民生活水平的不断提高，饮食习惯与饮食结构的改变，导致其发病率也逐年升高，病死率、致残率均较高，严重影响患者的生活质量及预后[1]。研究发现，急性脑梗死的发病主要是由于脑供血障碍引起脑组织缺血、缺氧而发生坏死、软化，进一步形成梗死灶[2]。有研究表明，长春西汀属于吲哚类生物碱药物，常用于治疗脑梗死，具有改善脑缺血区微循环、扩张脑血管、改善神经功能缺损的作用[3]。……