黄秀芬

DOI：10.16662/j.cnki.1674-0742.2017.16.127

[摘要] 目的 观察研究孟鲁司特联合沙美特罗替卡松治疗支气管哮喘的临床效果。 方法 便利选取2014年12月—2015年11月间在该院治疗的80例支气管哮喘患者为研究对象，将患者分组（对照组和研究组）并采用不同的用药方式进行治疗，并对治疗后的评价指标内容进行对比分析。结果采用孟鲁司特联合沙美特罗替卡松治疗的观察组41例患者在呼吸频率、心率、动脉血氧分压、动脉血二氧化碳分压（18.4±4.2）次/mmHg、（87.3±6.6）mmHg、（99.6±6.8）mmHg、（42.3±6.8）mmHg均优于采用沙美特罗替卡松治疗治疗的对照组；观察组的治疗总有效率达到97.56%优于对照组的87.17%，以上比较差异有统计学意义（P<0.05）。两组患者的pH值比较基本差异无统计学意义（P>0.05）。 结论 治疗支气管哮喘采用孟鲁司特联合沙美特罗替卡松具有较高的治疗有效率，且患者的各项生命体征值恢复理想，具有较好的临床应用价值。

[关键词] 孟鲁司特；沙美特罗替卡松；治疗；支气管哮喘；临床观察

[中图分类号] R562 [文献标识码] A [文章编号] 1674-0742（2017）06（a）-0127-03

Clinical Analysis of Montelukast and Salmeterol and Fluticasone Propionate in Treatment of Bronchial Asthma

HUANG Xiu-fen

Department of Respiration Medicine， Puer Peoples Hospital， Puer， Yunnan Province， 665000 China

[Abstract] Objective To observe and research the clinical effect of montelukast and salmeterol and fluticasone propionate in treatment of bronchial asthma. Methods 80 cases of patients with bronchial asthma admitted and treated in our hospital from December 2014 to November 2015 were convenient selected and divided into two groups according to different medication methods， the evaluation index content after treatment was compared and analyzed， and the observation group with 41 cases were treated with montelukast and salmeterol and fluticasone propionate， while the control group were treated with salmeterol and fluticasone propionate. Results The respiration frequency， heart failure， arterial partial pressure of oxygen and partial pressure of carbon dioxide in artery in the observation group were（18.4±4.2）times/min，（87.3±6.6）mmHg，（99.6±6.8）mmHg，（42.3±6.8）mmHg， which were better than those in the control group， and the total treatment effective rate in the observation group was better than that in the control group（97.56% vs 87.17%）， and the differences were statistically significant，（P<0.05） but the difference in the pH value between the two groups was not big（P>0.05）. Conclusion The effective rate of montelukast and salmeterol and fluticasone propionate in treatment of bronchial asthma is high， and the recovery of various vital signs of patients is ideal， and it is of better clinical application value.

[Key words] Montelukast； Salmeterol and fluticasone propionate； Treatment； Bronchial asthma； Clinical observation

支氣管哮喘是指表现反复发作性咳嗽、喘鸣和呼吸困难并伴有气道高反应性的可逆性、梗阻性呼吸道疾病，引发因素较多，通常认为与基因遗传、变应原（室内变应原、室外变应原）、职业性变应原、药物及食物添加剂等，并可在如空气污染、呼吸道病毒感染、妊娠以及剧烈运动、气候转变等情况下诱发[1-2]。临床为伴有哮鸣音的呼气性呼吸困难或发作性咳嗽、胸闷，干咳或咳大量白色泡沫痰甚至出现发绀等，夜间及凌晨发作。是影响人们身心健康的重要疾病，如不规范及时治疗可能致命[3]，为此对自2014年12月—2015年11月之间在该院治疗的80例支气管哮喘患者为研究对象尽心采用孟鲁司特联合沙美特罗替卡松治疗支气管哮喘的临床研究，现报道如下。……