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DOI：10.16662/j.cnki.1674-0742.2017.16.122

[摘要] 目的 探讨华蟾素注射液胸腹腔灌注治疗恶性胸腹腔积液的疗效。方法 回顾性分析2012年5月—2016年2月38例恶性胸腹腔积液患者应用华蟾素注射液胸腹腔灌注治疗的临床病例资料，统计观察其治疗效果及发生的相关不良反应情况。结果 38例恶性胸腹腔积液经1周期的华蟾素注射液胸腹腔灌注治疗后，治疗总有效率为89.47%（34/38），其中完全缓解13例（34.21%），有效21例（55.26%），无效4例（10.53%），有发生不同程度的疼痛16例、腹泻2例、恶心呕吐3例，均经及时对症干预处理后基本缓解，但均未发生骨髓抑制作用、肝肾损害或心律异常等不良反应情况。结论 华蟾素注射液胸腹腔灌注治疗的安全性好、有效性高、不良反应少、接受度强，是一种适合各类中晚期肿瘤患者发生恶性胸腹腔积液的高效治疗方法，具有进一步推广于临床进行实践应用的价值。

[关键词] 华蟾素注射液；胸腹腔灌注治疗；恶性胸腹腔积液

[中图分类号] R592 [文献标识码] A [文章编号] 1674-0742（2017）06（a）-0122-03

Analysis of Curative Effect of Pleural and Peritoneal Perfusion of Huachansu Injection in Treatment of Malignant Pleural Effusion

GUAN Rong

Department of Medical Oncology， Shihezi Peoples Hospital & Third Affiliated Hospital of Shihezi University Medical College， Shihezi， Xinjiang， 832000 China

[Abstract] Objective To discuss the curative effect of pleural and peritoneal perfusion of Huachansu Injection in treatment of malignant pleural effusion. Methods 38 cases of malignant pleural effusion patients treated with huachansu injection from May 2012 to February 2016 were selected and the treatment effect and related adverse reactions were counted and observed. Results After one-cycle treatment， the total treatment effective rate was 89.47%（34/38）， 13 cases were totally relieved （34.21%）， 21 cases were effective （55.26%）， 4 cases were ineffective （10.53%）， and there were 16 cases with different degrees of pains， 2 cases with diarrhea and 3 cases with vomiting and nausea， and all of these patients were basically relieved after the timely and symptomatic intervention， but there were no adverse reactions such as bone marrow suppression， liver and kidney damage， or abnormal cardiac rhythm. Conclusion The safety of pleural and peritoneal perfusion of huachansu injection is good with high effectiveness， fewer adverse reactions and strong acceptance， which is an effective treatment method that is suitable for patients with various tumors in middle and late stages， and it is worth clinical further practice and application.

[Key words] Huachansu injection； Pleural and peritoneal perfusion treatment； Malignant pleural effusion

惡性胸腹腔积液是恶性肿瘤疾病患者常发的一种临床并发症[1]。近年来，随着临床恶性肿瘤的发病率逐渐升高，恶性胸腹腔积液的临床发病率亦随之明显增高，严重影响到患者的生活品质，以及缩短其生存期[2]。虽然目前临床中西医学针对恶性胸腹积液的治疗措施多种多样，但在患者良好耐受的基础上，实现有效抑制其恶性胸腹积液病症的报道依然少有。通过全面总结华蟾素注射液的抗恶性肿瘤功效作用，并结合临床多项研究观察进展，得知华蟾素注射液具有性寒、有毒等特点[3]，而且其主要包含两大类活性成分：蟾毒内酯类和吲哚生物碱类，拥有直接破坏肿瘤细胞、促进血管收缩、抑制生成新生血管的特殊性作用[4]。……