周杰　王世岩

【摘要】 目的：探讨桑菊止咳颗粒治疗成人支原体肺炎的临床疗效及安全性。方法：选取2016年6月-2017年1月吉林省中医药科学院第一临床医院收治的72例成人支原体肺炎患者，采用随机数字表分为试验组和对照组，每组36例。试验组给予桑菊止咳颗粒1袋/次，2次/d，开水冲服；对照组给予阿奇霉素分散片0.5 g，饭后2 h口服。两组病例均可使用物理降温，对剧烈呛咳者，应适当予镇咳药并嘱其多饮水，补充维生素C等对症及一般治疗，两组疗程均为14 d。采集两组治疗前、治疗后3、7 d、疗程结束时中医四诊资料，分析两组治疗前后血尿常规、肝肾功能、胸片、肺炎支原体抗体（Gimp）等，进行疗效性及安全性评价。结果：试验组的综合疗效、中医证候疗效、中医症状疗效均优于对照组，差异均有统计学意义（P<0.05）。结论：桑菊止咳颗粒治疗成人支原体肺炎临床疗效显著，且有较高的安全性。

【关键词】 桑菊止咳颗粒； 成人支原体肺炎； 临床研究

Clinical Study of Sangju Zhike Granules in Treatment of 72 Adults with Mycoplasma Pneumonia/ZHOU Jie，WANG Shi-yan.//Medical Innovation of China，2017，14（16）：079-082

【Abstract】 Objective：To investigate the clinical efficacy and safety of Sangju zhike granules in the treatment of adult Mycoplasma pneumonia.Method：From June 2016 to January 2017，72 cases with Mycoplasma pneumonia were selected，they were divided into experimental group and control group according to the random number table method，36 cases in each group.The experimental group was treated with Sangju zhike granules 1 packet each time，mixed with warm water 2 times each day.The control group was given 0.5 g Azithromycin Dispersible Tablets，2 hours after the meal orally.They were all given the physical cooling，for patients who with severe choking，should be given appropriate antitussives treatment，more water，vitamin C and other symptomatic treatment.Two groups course of treatment both were 14 days.Before and after treatment 3 days，7 days，the treatment course end，the traditional chinese medicine（TCM）four diagnostic data of the two groups were collected，before and after treatment， the result of hematuria routine，liver and kidney function，chest X-ray and Mycoplasma pneumoniae antibody（MP-IgM） were analysed， the efficacy and safety of the tow groups were evaluated.Result：The comprehensive curative effect，TCM syndromic effect，TCM symptom of the experimental group were all better than those of the control group，the differences were statistically significant（P<0.05）.Conclusion：Sangju zhike granules in the treatment of adult mycoplasma pneumonia has good clinical efficacy and safety.

【Key words】 Sangju zhike granules； Mycoplasma pneumonia in adults； Clinical research

First-authors address：Jilin Provincial Academy of Traditional Chinese Medicine，Changchun 130021，China

doi：10.3969/j.issn.1674-4985.2017.16.022

目前我國肺炎支原体肺炎发病率不断升高，在前不久的一项7个城市12家医院参加的全国成人社区获得性肺炎（CAP）致病原调查中，肺炎支原体（MP）肺炎的比例达到了20.7%，已经超过了肺炎链球菌，为成人CAP的首要致病原[1]。肺炎支原体引起的CAP可出现在各年龄层，危害较大，严重可出现胸腔积液，阻塞性支气管炎，急性呼吸窘迫综合征肺纤维化等，甚至危及生命[2]，同时支原体感染也是慢性咳嗽和支气管哮喘的重要病因[3]，因此积极治疗十分必要。在成人肺炎支原体肺炎的治疗中，大环内酯类抗菌药物为首选，氟喹诺酮类、四环素类也用于肺炎支原体的治疗，但阿奇霉素耐药现象日益普遍。……