吴静

【摘要】 目的 探讨复方硼酸含漱液的药理毒理学。方法 60只小鼠为实验对象， 随机分为生理盐水组、阿司匹林组、复方硼酸含漱液低、中、高组， 各12只。另选取12只大鼠进行复方硼酸含漱液急性毒性试验。采用二甲苯所致的小鼠耳廓肿胀和角叉菜胶所致大鼠足趾炎症模型、热板法、扭体法以及体外抑菌试验， 观察复方硼酸含漱液的抗炎、镇痛以及抑菌作用。观察实验结果。结果 复方硼酸含漱液对二甲苯所致的小鼠耳廓肿胀有显著的抑制作用， 与生理盐水组比较差异具有统计学意义（P<0.05）；复方硼酸含漱液不同剂量组提高小鼠痛阈百分率与生理盐水组相比差异具有统计学意义（P<0.05）。复方硼酸含漱液对金黄色葡萄球菌、甲型链球菌等有较好的抑制及杀菌作用。并且安全低毒。结论 复方硼酸含漱液具有较好的抗炎镇痛以及抑菌作用， 并且疗效确切、低毒， 能促进患者的尽早康复。

【关键词】 复方硼酸含漱液；药理毒理学；临床研究

DOI：10.14163/j.cnki.11-5547/r.2016.08.216

Pharmacological and toxicological research of compound boric acid gargle WU Jing. Department of Pharmacy， Henan Province Rongjun Hospital， Xinxiang 453000， China

【Abstract】 Objective To investigate pharmacology and toxicology of compound boric acid gargle. Methods A total of 60 rats as study subjects were randomly divided into normal saline group， aspirin group， low， moderate and high compound borax solution groups， with 12 cases in each group. Another 12 rats were taken in acute toxicity test of compound borax solution. Anti-inflammatory， analgesic and bacteriostatic effects by compound borax solution were observed by hot plate test， writhing test and antibacterial experiment in vitro in xylene-induced rat auricle edema and carrageenin-induced rat toe inflammation models. Experimental findings were observed. Results Compound borax solution showed remarkable inhibiting effect on xylene-induced rat auricle edema， and its difference with the normal saline had statistical significance （P<0.05）. The difference of improved pain threshold proportion in various compound borax solution dosage groups had statistical significance with the normal saline group （P<0.05）. Compound borax solution showed good inhibiting and bactericidal effect on staphylococcus aureus and group A streptococcus， along with high safety and low toxicity. Conclusion Compound boric acid gargle provides remarkable anti-inflammatory， analgesic， and bactericidal effects. It can accelerate early rehabilitation in patients， with precise curative effect and low toxicity.

【Key words】 Compound boric acid gargle； Pharmacology and toxicology； Clinical research

含漱液在临床上的应用能有效地清除患者的口腔异味， 且能在很大程度上减少患者的口腔细菌、抗炎镇痛， 有效地防止患者龋齿的发生[1]。因此在临床上将含漱液作为牙周炎、冠周炎、牙龈炎以及口腔黏膜疾病等辅助治疗方式， 能显著地抑制患者菌斑的形成， 从而有效改善患者牙龈炎症的状况。复方硼酸含漱液是在传统口腔含漱液的基础上发展而来， 其中添加了甘油、麝香草酚以及普鲁卡因等， 经过临床上多年的使用未出现较大不良反应的发生[2]。但复方硼酸含漱液的处方成分包含消毒防腐药， 具有一定的毒性， 为了进一步研究复方硼酸含漱液的安全性及有效性， 本文对复方硼酸含漱液的药理毒理作用进行分析， 旨在为临床实践提供理论基础。现将具体研究内容整理报告如下。

1 材料与方法