山小薪

[摘要] 目的 對盐酸氨溴索治疗老年肺炎患者的临床疗效及安全性进行分析研究。方法 随机选取该院2014年8月—2016年8月期间收治的老年肺炎患者作为研究对象，共选择70例，并采用随机数字表法将其分为两组，每组35例。其中对照组患者采用吸氧支持和抗感染等常规治疗，而观察组患者则在常规治疗的基础上，增加盐酸氨溴索辅助治疗，对两组患者治疗后的临床疗效、症状恢复速度、咳痰量改善程度、咳嗽程度改善情况和不良反应发生情况进行观察分析。结果 观察组患者临床疗效显著优于对照组，治疗总有效率分别为97.14%和80.00%，数据比较差异有统计学意义（P<0.05）；观察组患者体温、咳嗽及肺部哮鸣音等症状改善和消失时间记录分别为（2.31±0.57）、（3.24±0.54）、（3.02±0.98）d均与对照组的（4.62±0.86）、（6.03±0.94）、（7.54±0.63）d相比均明显更短，数据比较差异有统计学意义（P<0.05）；治疗后，观察组咳痰量（0.62±0.08）分和咳嗽程度（0.84±0.14）分，评价指标与对照组患者（1.03±0.26）分、（1.26±0.25）分比较差异有统计学意义（P<0.05）；观察组患者治疗期间不良反应占比2.86%，与对照组患者（2.86%）相同，数据比较差异无统计学意义（P>0.05）。结论 对老年肺炎患者采用盐酸氨溴索治疗能够明显改善患者的临床症状，加快患者恢复速度，且安全性较高，值得在临床上推广应用。

[关键词] 盐酸氨溴索；老年肺炎；临床疗效

[中图分类号] R563.1 [文献标识码] A [文章编号] 1674-0742（2017）04（c）-0007-03

[Abstract] Objective To research the clinical curative effect and safety of ambroxol hydrochloride in treatment of senile pneumonia. Methods Random selection 70 cases of senile patients with pneumonia admitted and treated in our hospital from August 2014 to August 2016 were selected and randomly divided into two groups with 35 cases in each， the control group adopted the routine treatment of oxygen uptake support and anti-infection， while the observation group added the adjunctive treatment of ambroxol hydrochloride on the basis of the routine treatment， and the clinical curative effect， symptom recovery speed， improvement degree of expectoration amount， improvement of cough degree and occurrence of adverse reactions of the two groups were observed and analyzed. Results The clinical curative effect in the observation group was obviously better than those in the control group， and the total treatment effective rate was respectively 97.14% and 80.00% in the observation group and in the control group， and the differences between groups were statistically significant（P<0.05）， and the body temperature， cough and lung wheezing rale improvement and disappearance time in the observation group was obviously shorter than that in the control group[（2.31±0.57），（3.24±0.54），（3.02±0.98）d vs （4.62±0.86），（6.03±0.94），（7.54±0.63）d]， and the difference was statistically significant（P<0.05）， after treatment， the differences in the expectoration volume and cough degree between the observation group and the control group were obvious with statistically significant[（0.62±0.08）points， （0.84±0.14）points vs （1.03±0.26）points，（1.26±0.25）points]（P<0.05）， and the difference in the incidence rate of adverse reactions between the observation group and the control group during the treatment period was not statistically significant（2.86% vs 2.86%）（P>0.05）. Conclusion The ambroxol hydrochloride in treatment of senile pneumonia can obviously improve the clinical symptoms of patients and speed up the recovery of patients with high safety， which is worth clinical promotion and application.

[Key words] Ambroxol hydrochloride； Senile pneumonia； Clinical curative effect

肺炎主要为肺间质、肺泡及终末气道等炎症，本身存在较大的危害性，而老年肺炎患者则痰液黏稠和咳痰无力等特征，很可能因为气道阻塞危害生命，因此需要加强对老年肺炎祛痰治疗的研究[1]。盐酸氨溴作为溴已新在机体内的代谢物，能够明显起到稀化痰液和减轻炎症反应的作用，对治疗老年肺炎具有较高的应用价值[2]。该次研究随机选择2014年8月—2016年8月期间收治的老年肺炎患者70例作为探讨盐酸氨溴索治疗临床疗效及安全性的研究对象，取得了较好的效果，现报道如下。……