赵敬敬　李玉玲

【摘要】 目的：比較喜炎平注射液、磷酸奥司他韦颗粒及蓝芩口服液在流感样病例早期治疗中的临床效果。方法：选取95例早期就诊的流感样患者，随机分为三组，喜炎平注射液组30例，静脉滴注，250 mg/次，1次/d，共3 d；磷酸奥司他韦颗粒组31例，口服，75 mg/次，2次/d，共3 d；蓝芩口服液组34例，口服，20 mL/次，3次/d，共3 d。比较三组患者治疗效果和不良反应发生情况。结果：喜炎平注射液组的发热、头痛、咳嗽缓解时间均明显短于磷酸奥司他韦颗粒组与蓝芩口服液组（P<0.05），磷酸奥司他韦颗粒组与蓝芩口服液组比较，差异均无统计学意义（P>0.05）；喜炎平注射液组肌痛缓解时间明显短于蓝芩口服液组（P<0.05），与磷酸奥司他韦颗粒组比较，差异无统计学意义（P>0.05）；蓝芩口服液组咽痛缓解时间最短，与其他两组比较差异均有统计学意义（P<0.05）。三组卡他症状的缓解时间两两比较，差异均无统计学意义（P>0.05）。95例患者中有8例发生不良反应，症状轻，各组间不良反应发生率比较，差异均无统计学意义（P>0.05）。结论：喜炎平注射液的早期使用能明显缩短流感样症状发热、头痛、咳嗽的持续时间，减轻症状的严重程度，适合在临床中推广使用。

【关键词】 流行性感冒； 磷酸奥司他韦颗粒； 喜炎平注射液； 蓝芩口服液； 临床观察

Study of Clinical Effect of Xiyanping Injection，Oseltamivir Phosphate Granules and Lanqin Oral Liquid in Treatment of Influenza-like Illness/ZHAO Jing-jing，LI Yu-ling.//Medical Innovation of China，2017，14（06）：040-043

【Abstract】 Objective：To compare the effects of Xiyanping Injection，Oseltamivir Phosphate Granules and Lanqin Oral Liquid in treating influenza-like illness（ILI）.Method：A total of 95 patients were divided into three randomized groups.The Xiyanping Injection group including 30 cases were given 250 mg/time，1 time/d，a total of 3 d，intravenous drip.The Oseltamivir Phosphate Granules group including 31 cases were given 75 mg/time，2 times/d，for 3 d，oral.The Lanqin Oral Liquid group including 34 cases were given 20 mL/time，3 times/d，for 3 days，oral.The effect and adverse reactions were compared between the three groups.Result：The fever，headache，cough relief time of Xiyanping Injection group，were significantly shorter than those in Oseltamivir Phosphate Granules group and Lanqin Oral Liquid group（P<0.05），the Oseltamivir Phosphate Granules compared with Lanqin Oral Liquid group，there were no significant differences（P>0.05）；the muscle pain relief time of Xiyanping Injection group was significantly shorter than that in Lanqin Oral Liquid group（P<0.05），compared with Oseltamivir Phosphate Granules group，the difference was not statistically significant（P>0.05）；the angina relief time of Lanqin Oral Liquid group was the shortest，compared with the other two groups were statistically significant（P<0.05）.The differences of the catarrh relief time between the three groups were no significant（P>0.05）.95 patients with adverse reactions occurred in 8 cases，mild symptoms，there were no significant differences in the incidence of adverse reactions between the three groups（P>0.05）.Conclusion：The early use of Xiyanping Injection can significantly reduce the flu like symptoms of fever，headache，cough duration，reduce the severity of symptoms，suitable for use in clinical.

【Key words】 Influenza； Oseltamivir Phosphate Granules； Xiyanping Injection； Lanqin Oral Liquid； Clinical observation

First-authors address：Civil Aviation General Hospital，Beijing 100025，China

doi：10.3969/j.issn.1674-4985.2017.06.011

流行性感冒（简称流感）是由流感病毒引起的急性呼吸道传染病，传染性强，发病率高。流感病毒可分为甲（A）、乙（B）、丙（C）三型，经由个体间的气溶胶吸入而得到迅速传播。流感高发于冬春季节，通常由甲型H1N1、H3N2及乙型流感病毒引起，在流感流行季节，流感样病例（influenza-like illness，ILI）明显增多，主要症状为发热（腋下体温≥38 ℃），伴咳嗽或咽痛之一，ILI缺乏实验室确定为某种病原体的依据。对于实验室诊断的流感病毒感染，西药磷酸奥司他韦作为首选抗病毒药物疗效明确，并且用于早期ILI治疗效果也得到验证，但磷酸奥司他韦存在较明显的不良反应，如消化道反应。喜……