陈玉兰　杨秀芳　郑铠军　林蔷　简伟华　丁俊彩

【摘要】 目的：探讨妊娠期甲状腺功能亢进（甲亢）的治疗情况对新生儿的影响。方法：选取2011年9月-2016年9月本院患有甲亢的孕妇所生新生儿92例为试验组，另选择同期住院的200例无任何并发症的健康孕妇的新生儿为健康对照组。92例试验组新生儿根据孕妇期甲亢治疗情况分为甲亢控制组与甲亢未控制组，甲亢控制组均口服丙硫氧嘧啶，甲亢未控制组未服药或未正规服药。调查分析各组新生儿的转归情况。结果：甲亢组新生儿中早产儿、低体重儿、新生儿窒息、新生儿甲状腺功能低下、新生儿甲状腺功能亢进、高胆红素血症的发生率，均较健康对照组高，差异均有统计学意义（P<0.05）；甲亢控制组早产儿、低体重儿、畸形、新生儿窒息、新生儿甲状腺功能低下、新生儿甲状腺功能亢进、高胆红素血症的发生率，均低于甲亢未控制组，差异均有统计学意义（P<0.05）。结论：妊娠期甲亢会对新生儿造成一定影响，对妊娠期甲亢患者进行积极有效的治疗能够显著改善新生儿的健康水平。

【关键词】 妊娠； 甲状腺功能亢进； 新生儿

Effect of Different Control State of Hyperthyroidism during Pregnancy on Neonates/CHEN Yu-lan，YANG Xiu-fang，ZHENG Kai-jun，et al.//Medical Innovation of China，2017，14（06）：048-051

【Abstract】 Objective：To explore the effect of the treatment of hyperthyroidism in pregnancy on neonates.Method：Ninety-two neonates born by pregnant with hyperthyroidism from September 2011 to September 2016 in our hospital were selected as the experimental group，another 200 healthy pregnant women without any complications were selected as healthy control group.Then 92 neonates born by pregnant with hyperthyroidism were divided into the treatment of hyperthyroidism control group and uncontrolled group according to the treatment of pregnant women with hyperthyroidism.The control of hyperthyroidism group were given propylthiouracil，uncontrolled group did not take medicine or not regular medication.The outcomes in different groups were investigated and analyzed.Result：The incidence rate of premature infants，low birth weight，neonatal asphyxia，neonatal hypothyroidism，neonatal hyperthyroidism and hyperbilirubinemia were in the pregnancy and hyperthyroidism group，which were higher than those in healthy control group，the differences were statistically significant（P<0.05）.The incidence rate of premature infants，low birth weight，deformity，neonatal asphyxia，neonatal hypothyroidism，neonatal hyperthyroidism and hyperbilirubinemia were in the control of hyperthyroidism，which were lower than those in uncontrolled group，the differences were statistically significant（P<0.05）.Conclusion：Pregnancy combined with hyperthyroidism has a certain impact on neonates，so the positive and effective treatment for the patients with hyperthyroidism during pregnancy can significantly improve the health of the newborn.

【Key words】 Pregnancy； Hyperthyroidism； Neonate

First-authors address：Zhongshan Peoples Hospital，Zhongshan 528400，China

doi：10.3969/j.issn.1674-4985.2017.06.013

妊娠期甲狀腺功能亢进（甲亢）是指在妊娠期体内因甲状腺激素分泌过多而导致的一系列临床表现的综合性症状。国内报道发病率为0.1%～0.2%，国外为0.05%～0.20%[1]。妊娠合并甲状腺功能亢进会导致母婴多项严重并发症，对于新生儿可导致甲状腺功能异常、早产、低出生体重、新生儿窒息、死胎、宫内发育迟缓、先天畸形、新生儿高胆红素血症等[2-3]。同时对新生儿以后的智力发育也有影响[4]。本研究将本院近5年收治的92例患甲亢孕妇所生新生儿资料作回顾性分析，现报道如下。

1 资料与方法

1.1 一般资料 选取2011年9月-2016年9月广东省中山市人民医院收治的92例符合妊娠期甲亢孕妇所生新生儿为研究对象，均妊娠至28周以后，年龄20～35岁，平均（29.0±5.2）岁；……