王圣识　孙铁权　龙梅欢　庄博

【摘要】 目的：分析觀察氯雷他定联合双氯芬酸钠滴眼液治疗过敏性结膜炎的临床疗效。方法：选取2014年1月-2016年3月期间于本院诊治的过敏性结膜炎患者136例，根据患者自选治疗方案的不同分为观察组74例和对照组62例。对照组患者给予单纯氯雷他定片治疗，观察组患者给予氯雷他定片联合双氯芬酸钠滴眼液治疗。分析比较两组患者的不良反应发生率和治疗前，治疗7、14 d的临床疗效及临床症状总积分变化。结果：治疗前，两组患者的临床症状积分比较差异无统计学意义（P>0.05）；治疗7、14 d后，两组患者的临床症状积分均显著降低，治疗14 d后的临床症状积分小于治疗7 d，观察组的临床症状积分小于对照组，比较差异均有统计学意义（P<0.05）。治疗7 d后，观察组患者的临床疗效优于对照组，比较差异有统计学意义（P<0.05）；治疗14 d后，两组患者的临床疗效均显著提高，观察组患者的临床疗效优于对照组，比较差异均有统计学意义（P<0.05）。两组患者均未出现明显不良反应症状。结论：相对于单纯使用氯雷他定片治疗，氯雷他定联合双氯芬酸钠滴眼液治疗过敏性结膜炎的临床疗效更为显著，值得推广使用。

【关键词】 氯雷他定片； 双氯芬酸钠滴眼液； 过敏性结膜炎； 临床疗效

Observe the Clinical Effect of Loratadine Combined with Diclofenac Sodium Eye Drops for the Treatment of Allergic Conjunctivitis/WANG Sheng-shi，SUN Tie-quan，LONG Mei-huan，et al.//Medical Innovation of China，2016，13（31）：128-131

【Abstract】 Objective：To analyze the clinical efficacy of Loratadine combined with Diclofenac Sodium eye drops for the treatment of allergic conjunctivitis.Method：136 patients with allergic conjunctivitis in our hospital form January 2014 to March 2016 were selected and divided into observation group of 74 cases and control group of 62 cases according to the different treatment options.Control group was treated with simple Loratadine eye drops， and observation group was treated with Loratadine combined with Diclofenac Sodium eye drops.The incidence of adverse reactions of the two groups were analyzed and compared.The total score of clinical symptoms and clinical efficacy of 7 and 14 d before treatment were analyzed.Result：Before treatment，the clinical symptom score were compared between the two groups was not statistically significant（P>0.05）；the treatment of 7 and 14 d after treatment，the clinical symptom score of two groups were significantly decreased，after 14 d treatment the clinical symptom score was lower than after 7 d treatment， observation group of that was less than control group，there were statistical significant differences（P<0.05）.After 7 d treatment，the clinical curative effect of observation group was better than control group，the difference was statistically significant （P<0.05）；after 14 d treatment，the clinical efficacy of the two groups were significantly improved， observation group of that was better than control group，the differences were statistically significant（P<0.05）.There were no obvious adverse reactions in the two groups.Conclusion：Compared with only using chlorine thunder Loratadine tablets in treatment，Loratadine combined with Diclofenac Sodium eye drops in the treatment of the clinical efficacy of allergic conjunctivitis is more significant，it is worth to promote.

【Key words】 Loratadine tablets； Diclofenac Sodium eye drops； Allergic conjunctivitis； Clinical curative effect

First-authors address：Huludao Central Hospital，Huludao 125000，China

doi：10.3969/j.issn.1674-4985.2016.31.037

过敏性结膜炎是由变应原激发、IgE介导的眼部炎症疾病，主要包括I型和IV型超敏反应，是临床常见的非感染性眼部疾病之一[1]。在我国，过敏性结膜炎的发病率高达22%左右，且随着化妆品使用率的不断上升和环境污染加剧，过敏性结膜炎的发病率呈逐年上升趋势[2]。本文分析观察氯雷他定联合双氯芬酸钠滴眼液治疗过敏性结膜炎的临床疗效，现报道如下。

1 资料与方法

1.1 一般资料 选取2014年1月-2016年3月期间于本院诊治的过敏性结膜炎患者136例，根据患者自选治疗方案的不同分为观察组74例和对照组62例。观察组患者中男39例，女35例；年龄16～67岁，平均（35.39±12.68）岁；病程7～26 d，平均（12.22±2.84）岁。对照……