苏如洪

摘 要 目的： 探讨运动训练联合注射玻璃酸钠与口服氨基葡萄糖治疗膝关节骨性关节炎的疗效。方法： 选取膝关节骨性关节炎（KOA）患者68例，随机分为对照组和研究组各34例，对照组患者均给予注射玻璃酸钠联合口服氨基葡萄糖治疗，而研究组患者则在对照组的基础上进行变速变负荷运动训练。比较2组患者的临床疗效和不良反应发生情况。结果：研究组患者的临床疗效为88.23%，显著高于对照组的70.59%（P<0.05）；研究组患者治疗后的VAS疼痛评分和膝关节功能评分分别为（3.52±1.14）分和（81.31±0.74）分，显著优于对照组的（5.43±1.21）分和（68.74±0.87）分（P<0.05）；研究组患者治疗后的生理功能、生理职能、躯体疼痛、总体健康、社会功能、活力、情感职能和精神健康共8个维度的评分均高于对照组（P<0.05）；2组患者治疗期间均未出现严重的不良反应。结论： 变速变负荷运动训练联合注射玻璃酸钠与口服氨基葡萄糖治疗KOA可有效改善患者的膝关节功能和生活质量，值得应用于临床。

关键词 运动训练 玻璃酸钠 氨基葡萄糖 膝关节骨性关节炎 临床疗效

中图分类号：R455； R684.3 文献标识码：B 文章编号：1006-1533（2016）19-0027-04

Effects of athletic training combined with sodium hyaluronate and glucosamine in the treatment of 34 cases of patients with knee osteoarthritis*

SU Ruhong**

（The Peoples Hospital of Wannian County， Shangrao 335500， China）

ABSTRACT Objective： To discuss the effects of athletic training combined with sodium hyaluronate and glucosamine in the treatment of patients with knee osteoarthritis （KOA）. Methods： Sixty-eight patients with KOA were selected and randomly divided into a control group and a research group with 34 patients each. The control group was treated with sodium hyaluronate and glucosamine while the observation group was additionally treated with athletic training besides the therapies for the control group. The clinical effects and the occurrence of adverse reactions were compared between the two groups before and after treatment. Results： The clinical effectiveness rate was obviously higher in the research group （88.23%） than in the control group （70.59%）（P< 0.05）. VAS pain scores and Lysholm knee scores were （3.52±1.14） and （81.31±0.74） in the research group and （5.43±1.21） and（68.74±0.87） in the control group after treatment， respectively， which were much better in the research group than in the control group （P< 0.05）. Eight dimensional scores including physiological and physical function， body pain， general health， social function， dynamic， emotional function and mental health were all higher in the research group than in the control group after treatment （P< 0.05）. There were no serious adverse reactions occurred in both groups during treatment. Conclusion： Knee function and quality of life of the patients with KOA can be effectively improved by variable velocity and resistance training combined with the injection of sodium hyaluronate and oral administration of glucosamine， which are worthy of application in clinic.

KEY WORDS athletic training； sodium hyaluronate； glucosamine； knee osteoarthritis； clinical effects

膝关节骨性关节炎（ knee osteoarthritis，KOA）是临床上常见的一种慢性骨关节疾病，多发于中老年人，临床表现主要为疼痛难忍、关节活动障碍等临床症状[1]。随着我国社会人口老龄化的加重，KOA的发病率呈逐年上升的趋势，严重影响我国中老年人的生活质量。非甾体类抗炎镇痛药和糖皮质激素是治疗KOA的重要药物之一，但随着临床应用的增多，其局限性也逐渐显露。研究显示[2]，非甾体类抗炎镇痛药和糖皮质激素只能暂时缓解患者的疼痛，并不能达到远期的治疗效果，且长期用药，可出现严重的不良反应，从而影响患者的生活质量。近年来国内外研究报道，科学的运动训练可有效改善患者临床症状和膝关节功能，已引起人们的广泛关注。本研究通过运动训练联合注射玻璃酸钠与口服氨基葡萄糖的综合治疗，旨在探讨其治疗KOA的临床疗效。

1 资料与方法……