正常儿童脑白质发育的DTI研究
2016-09-19鲁雪红楼俭茹
鲁雪红,栾 立,楼俭茹,王 伟
(新疆医科大学附属中医医院影像中心,新疆 乌鲁木齐 830000)
正常儿童脑白质发育的DTI研究
鲁雪红,栾立,楼俭茹,王伟
(新疆医科大学附属中医医院影像中心,新疆 乌鲁木齐 830000)
目的:用DTI研究正常儿童脑白质发育特点。方法:收集50例1~12岁健康儿童脑DTI图像,分析第1组(1~3岁)、第2组(4~6岁)、第3组(7~9岁)及第4组(10~12岁)4个年龄组与脑白质内囊前肢、内囊后肢、胼胝体膝部、胼胝体压部及尾状核头部5个部位的各向异性指数(FA)值、ADC值的相关性及差异性。结果:内囊前肢、内囊后肢、胼胝体膝部及胼胝体压部的FA值与年龄呈正相关,尾状核头部的FA值与年龄呈负相关;内囊前肢、内囊后肢、胼胝体膝部、胼胝体压部及尾状核头部的ADC值均与年龄呈负相关。第1、2组间及第2、3组间内囊前肢、内囊后肢、胼胝体膝部及胼胝体压部的FA值、ADC值差异均有统计学意义(均P<0.05);第3、4组组间胼胝体膝部及胼胝体压部的FA值、ADC值差异均有统计学意义(均P<0.05)。结论:DTI的FA值和ADC值能反映脑白质发育差异。
磁共振成像,弥散;弥散张量成像;脑白质纤维;各向异性
[Abstract]Objective:To investigate the difference of the different cerebral white matter and elucidate changes of the cerebral white matter in normal children.Methods:Collection the DTI images of the cerebral white matter of 50 healthy children,age range from 1 to 12 years,dividedinto 4 groups(group 1:1-3y,group 2:4-6y,group 3:7-9y and group 4:10-12y).Analysis the correlation of the age and the FA values and ADC values of the 5 regions:anterior limb of the internal capsule(ALIC),posterior limb of the internal capsule(PLIC)、genu of corpus callosum(GCC)、splenium of corpus callosum(SCC)and head of caudate nucleus(HCN)of the cerebral white matter.Analyze the difference of the FA values and ADC values of 4 age groups.Results:The FA values increased with increasing age in ALIC、PLIC,GCC,SCC,while decreased with increasing age in HCN.The ADC values increased with increasing age in ALIC,PLIC,GCC,SCC and HCN.There were difference in ALIC,PLIC,SCC and GCC in FA and ADC values between group 1 and 2,group 2 and 3.There were significant difference in FA and ADC values between group 3 and 4 in SCC and GCC.Conclusion:DTI can be used to analyze the difference of cerebral white matter of healthy children.
[Key words]Diffusion Magnetic resonance imaging;Diffusion tensor imaging;Cerebral white matter fiber;Anisotropy
本文以1~12岁健康儿童大脑DTI图像为研究对象,以了解正常儿童脑白质各向异性指数(FA)值、ADC值正常范围,探讨FA值、ADC值的分布规律。
1 资料与方法
1.1一般资料收集2013年1月至2014年6月于我院检查的1~12岁健康儿童50例,其中男27例,女23例,均为足月;平均年龄7.4岁;汉族31例,少数民族19例(其中回族9例、维吾尔族5例、哈萨克族3例、蒙古族2例)。纳入标准:①无颅脑发育异常、新生儿缺血缺氧病史及家族精神病史;……
