汤岚凤，王安琴，王　敏，姜　曼，武红利，李传富

（1.安徽中医药大学研究生院，安徽 合肥 230000；2.安徽中医药大学第一附属医院影像中心，安徽 合肥 230000）



论著

基于体素分析技术在肝豆状核变性MRI研究中的应用价值

汤岚凤1，王安琴1，王敏1，姜曼1，武红利1，李传富2

（1.安徽中医药大学研究生院，安徽 合肥 230000；2.安徽中医药大学第一附属医院影像中心，安徽 合肥 230000）

目的：探讨基于体素分析（voxel-based analysis，VBA）图像方法在肝豆状核变性（Wilson's disease，WD）MRI研究中的应用价值。方法：通过34例WD患者和30例健康志愿者的定量磁化率成像（quantitative susceptibility mapping，QSM）和DTI数据的VBA组间比较，检出WD患者大脑铁沉积及各向异性指数（FA）值异常的脑区，分析这种方法与常规基于ROI方法研究的优势与不足。结果：WD患者较正常人，双侧丘脑、双侧豆状核、双侧尾状核、双侧红核、双侧黑质、双侧颞叶、右侧岛叶和左侧顶下小叶等脑区的铁沉积含量增加，部分白质等脑区的铁沉积含量减少；双侧丘脑的背外侧核和腹外侧核、双侧豆状核、双侧尾状核及双侧红核等脑区的FA值升高，双侧丘脑内侧核及白质等脑区的FA值降低。结论：VBA图像方法具有能够发现未知区域病变、病变区域精确定位，以及研究客观等方面的优势，是一种很有价值的WD的MRI研究方法。

基于体素分析；肝豆状核变性；磁共振成像

［Abstract］Objective：To explore the application value of voxel-based analysis（VBA）in MRI study of Wilson's disease. Methods：34 patients with WD and 30 cases of healthy controls were recruited for the QSM study and DTI study.With voxel-based analysis，the iron deposition and FA value of WD patients were compared with the control group in order to find the changed brain areas in patient group.These areas were further compared with common ROIs used in conventional MRI studies to investigate the VBA efficiency of pathology detection.Results：Compared with the control group，the patient group demonstrated significantly increased iron deposition in bilateral thalamus，lentiform nucleus，caudate nucleus，red nuclears，substantia nigra，temporal lobe，as well as right insula and left inferior parietal lobule，while decreased iron deposition was found in some white matter areas.The patient group showed significantly increased FA value in bilateral dorsal lateral and ventral lateral nucleus of thalamus，lentiform nucleus，caudate nucleus and bilateral red nucleus.while significantly decreased FA value was demonstrated in bilateral medial thalamic nucleus and widespread areas of white matter.Conclusion：With the method of voxel-based analysis，not only the conventional lesion areas are detected，but some brand new areas of abnormality are also found.Futhermore，this method could provide more detailed and precise anatomical information and overcome the weakness of conventional method of manually drawing ROI.Therefore，it is concluded that VBA is a valuable method in Wilson's disease study of MRI.

［Key words］Voxel-based analysis；Hepatolenticular degeneration；Magnetic resonance imaging

常规的颅脑MRI研究方法多手工绘制ROI以确定相应ROI在患者与正常人之间是否存在差异。但手工绘制ROI易受主观因素及先验知识的影响，重复性较低，且难以全面分析病变的细节特征，特别是对一些常规影像学表现不明显且可能累及全脑的非局灶性病变。……