邓晓峰内蒙古科技大学包头医学院第二附属医院心内科，内蒙古包头 014030

观察琥珀酸美托洛尔缓释片治疗慢性充血性心力衰竭的疗效

邓晓峰
内蒙古科技大学包头医学院第二附属医院心内科，内蒙古包头 014030

目的采用琥珀酸美托洛尔缓释片治疗慢性充血性心力衰竭的临床有效性观察。方法随机取该院2013年12月—2014年12月收治的慢性充血性心力衰竭患者70例，分为两组，对照组采用常规治疗，实验组采用琥珀酸美托洛尔缓释片治疗，分析两组治疗效果。结果实验组治疗后LVEDD（55.19±0.97）mm、LVESD（40.39±0.79）mm、LVEF （49.82±0.93）%、6MWT（679.25±21.05）mm、BNP为 （465.82±11.57）μg/L，对照组治疗后LVEDD（59.87±0.76）mm、LVESD （45.97±1.02）mm、LVEF（40.37±0.87）%、6MWT（531.29±19.87）m、BNP为（583.29±12.65）μg/L，实验组各项心功能指标改善程度优于对照组（P＜0.05）。且实验组治疗后的总有效率97.14%，高于对照组的77.14%（P＜0.05）；且实验组治疗后生理功能（71.06±2.51）分、社会功能（70.95±2.54）分、心理功能（69.86±2.34）分、躯体疼痛（66.97±2.85）分、健康状况（69.87±2.57）分，对照组治疗后生理功能（60.39±3.27）分、社会功能（61.98±2.53）分、心理功能（60.29±2.58）分、躯体疼痛（56.87±1.24）分、健康状况（59.87±2.56）分，组间比较差异有统计学意义（P＜0.05）。结论琥珀酸美托洛尔缓释片治疗慢性充血性心力衰竭的临床效果显著，值得推广。

琥珀酸美托洛尔缓释片；治疗；慢性充血性心力衰竭

［Abstract］Objective To observe the clinical effectiveness of metoprolol succinate sustained-release tablet in treatment of chronic congestive heart failure.Methods 70 cases of patients with chronic congestive heart failure admitted and treated in our hospital from December 2013 to December 2014 were selected and divided into two groups，the control group were treated with conventional method，the experimental group were treated with metoprolol succinate sustained-release tablet，the treatment effects of the two groups were analyzed.Results The LVEDD，LVESD，LVEF，6MWT and BNP after treatment were respectively（55.19±0.97）mm，（40.39±0.79）mm，（49.82±0.93）%，（679.25±21.05）mm and（465.82±11.57）μg/L in the experimental group and（59.87±0.76）mm，（45.97±1.02）mm，（40.37±0.87）%，（531.29±19.87）m and（583.29±12.65）μg/L in the control group，the improvement degrees of various heart function indexes in the experimental group were better than those in the control group，P＜0.05，the total effective rate after treatment in the experimental group was higher than that in the control group，（97.14%vs 77.14%），P＜0.05，the physical function score，social function score，mental function，body pain score and health condition score after treatment were respectively （71.06±2.51）marks，（70.95±2.54）marks，（69.86± 2.34）marks，（66.97±2.85）marks and（69.87±2.57）marks in the experimental group and（60.39±3.27）marks，（61.98±2.53）marks，（60.29±2.58）marks，（56.87±1.24）marks and（59.87±2.56）marks，and the differences between groups were obvious by comparison，P＜0.05.Conclusion The clinical effect of metoprolol succinate sustained-release tablet in treatment of chronic congestive heart failure is obvious，which is worth promotion.

［Key words］Metoprolol succinate sustained-release tablet；Treatment；Chronic congestive heart failure

慢性充血性心力衰竭是心肌病、高血压、心肌梗塞等心脏疾病终末阶段，该病的预后较差，病死率较高［1］。临床上，多采用抗心衰治疗慢性充血性心力衰竭，但其远期效果欠佳；因此，选择一种切实有效的治疗方法，改善慢性充血性心力衰竭患者的预后，提升其生活及生存的质量尤为关键［2］。琥珀酸美托洛尔缓释片是一种新型的β受体阻滞剂，该药因其血药浓度较高、药效较为稳定、吸收持久等优势被广泛应用于慢性心力衰竭的治疗中。……