H型高血压患者血清Hcy、Cyst-C、UA水平与颈动脉粥样硬化的关系

2016-09-05曹栋河南省南阳市第一人民医院神经内科河南南阳573010

中外医疗 2016年11期

曹栋河南省南阳市第一人民医院神经内科，河南南阳 573010

曹栋
河南省南阳市第一人民医院神经内科，河南南阳 573010

目的探究H型高血压患者颈动脉粥样硬化与血清Hcy、Cyst-C、UA水平的关系。方法方便选取2013年1月—2014年1月于该院治疗的88例H型高血压患者，分为观察组和对照组2组，每组44人，前者超声检查颈动脉内膜中层厚度（IMT）正常，后者IMT明显增厚，观察两组间血清Hcy、Cyst-C、UA水平指标差异。结果观察组血清Hcy、Cyst-C、UA指标显著高于对照组（P＜0.05），上述指标为IMT独立危险因素，IMT与其明显相关（r=0.28、0.33、0.27，P＜0.05）。结论H型高血压患者血清Hcy、Cyst-C、UA水平与颈动脉粥样硬化明显相关，可成为其早期诊断指标。

颈动脉粥样硬化；关系；H型高血压患者；Hcy；Cyst-C；UA

［Abstract］Objective To research the correlation between serum Hcy，Cyst-C and UA levels in patients with H-type hypertension and carotid atherosclerosis.Methods 88 cases of patients with H-type hypertension treated in our hospital from January 2013 to January 2014 were divided into two groups with 44 cases in each，the IMT of the former was normal after ultrasonic examination，the IMT of the latter was obviously thickened，and the differences in the indexes of serum Hcy，Cyst-C and UA levels between the two groups were observed.Results The serum Hcy，Cyst-C and UA indexes in the observation group were obviously higher than those in the control group（P＜0.05），the above indexes were the independent risk factors of IMT，and the IMT was obviously correlated with them（r=0.28，0.33，0.27，P＜0.05）.Conclusion The serum Hcy，Cyst-C and UA levels in patients with H-type hypertension were obviously correlated with carotid atherosclerosis，which can be the early diagnostic indexes.

［Key words］Carotid atherosclerosis；Correlation；Patients with H-type hypertension；Hcy；Cyst-C；UA

随着人们生活与饮食习惯的改变，高血压逐渐成为临床上常见病与高发病，高血压常常伴随其他心血管疾病，颈动脉粥样硬化（CAS）就是与高血压密切相关的动脉硬化疾病，血压升高能损伤动脉内膜，使动脉壁变厚并失去弹性，而颈动脉某些部位的内膜下脂质沉积，并伴纤维基质成分和平滑肌细胞增生，会逐渐发展成动脉粥样硬化性斑块。研究表明，IMT可以有效反映动脉粥样硬化状况。方便选取88例于2013年1月—2014 年1月在该院治疗的H型高血压患者血清Hcy、Cyst-C、UA水平进行调查，分析其与IMT的关系，现报道如下。