陈艳波齐齐哈尔市中医医院肿瘤科，黑龙江齐齐哈尔 161005

肾癌术后辅助性免疫治疗临床疗效评价

陈艳波
齐齐哈尔市中医医院肿瘤科，黑龙江齐齐哈尔 161005

目的探究肾癌术后辅助性免疫治疗对患者肿瘤复发转移及预后的影响。方法 方便选取并回顾性分析该院2010年3月—2012年3月收治的60例RCC患者的临床资料，对肾癌术后辅助性免疫治疗以及其他临床因素对患者预后的影响进行评价。结果该组60例RCC患者，术后转移与复发患者12例，死亡9例，单因素分析显示，T分期、肿瘤直径和有无辅助性免疫治疗与术后肿瘤转移和复发情况有关（P＜0.05），病理类型、T分期、肿瘤直径和有无辅助性免疫治疗与患者术后生存情况有关（P＜0.05）；多因素分析显示，免疫治疗是影响术后肿瘤转移复发和患者生存情况的独立危险因素（P＜0.05）。结论肾癌术后辅助性免疫治疗对术后肿瘤转移复发及患者生存情况可产生直接影响，有助于降低术后肿瘤转移复发风险，延长患者生存时间。

肾细胞癌；根治性肾切除术；免疫治疗

［Abstract］Objective To research the effect of adjuvant immunotherapy after nephrectomy on tumor recurrence and metastasis and prognoses of patients.Methods The clinical data of 60 cases of RCC patients admitted and treated in our hospital from March 2010 to March 2012 were retrospectively analyzed，and the effect of adjuvant immunotherapy after nephrectomy and the other clinical factors on the prognoses of patients was evaluated.Results In this group，postoperative metastasis and recurrence occurred to 12 cases，death occurred to 9 cases，the single factor analysis revealed that T staging，tumor diameter and adjuvant immunotherapy or not were correlated with the metastasis and recurrence of postoperative tumors（P＜0.05），the pathological type，T staging，tumor diameter and adjuvant immunotherapy or not were correlated with the postoperative survival conditions（P＜0.05），the multiple factor analysis revealed that immunotherapy was the independent risk factor of influencing the metastasis and recurrence of postoperative tumors and the survival conditions（P＜0.05）.Conclusion Adjuvant immunotherapy after nephrectomy can impose a direct effect on the metastasis and recurrence of postoperative tumors and the survival conditions of patients，and it contributes to reducing the recurrence risks of postoperative tumor metastasis and prolonging the survival time of patients.

［Key words］Renal cell cancer；Radical nephrectomy；Immunotherapy

近年来，随着生物技术的发展以及免疫治疗在临床上的推广，相关方法在转移性RCC治疗中开始应用，并在关注其术后辅助治疗价值，逐渐倾向于将免疫治疗作为RCC术后的辅助治疗方法［1-2］。目前临床对于免疫治疗能否改善患者预后也尚未达成共识，但是作为辅助性治疗可供选择方法之一，有必要明确其与术后预后之间的关系，该研究收集该院2010年3月—2012 年3月收治的60例RCC患者的临床资料进行回顾性分析，旨在探讨术后辅助性免疫治疗对患者预后的影响，现报道如下。……