陈嫄陈春富肖萧张颖博李婴婴

中文版偏头痛患者药物依赖性问卷信度和效度研究☆

陈嫄*陈春富*肖萧*张颖博*李婴婴*

目的评价中文版偏头痛患者药物依赖性问卷的信度和效度。方法 选取115例合并药物依赖综合征的偏头痛患者，收集其临床资料并进行中文版偏头痛患者药物依赖性问卷的测试。采用重测信度、内部一致性信度评价分析问卷信度，采用内容效度和结构效度评价分析问卷效度。结果量表的重测信度除条目11和条目16为0.558和0.443以外，其余条目的重测信度均大于0.7。总量表的Cronbach’α系数为0.820，各个维度的Cronbach’α系数均＞0.7。量表的各条目得分和相应维度总分之间的相关系数在0.595～0.962之间。因子分析共提取7个特征根大于1的因子，可解释总变异的76.3%，在相应项目上均有较强的因子载荷。结论中文版偏头痛患者药物依赖性问卷具有较好的信度和效度，适合临床推广应用。

偏头痛中文版头痛患者药物依赖性问卷信度效度

【Abstract】Objective To evaluate the reliability and validity of a medication dependence questionnaire in migraineurs of the Chinese version.Methods One hundred fifteen migraine patients with drug dependence syndrome were included and their clinical data were then collected.All the subjects were interviewed with the medication dependence questionnaire in migraineurs of the Chinese version.The reliability and validity of the questionnaire were evaluated according to test-retest reliability and internal consistency reliability，and the content validity and construct validity respectively.Results The test-retest reliability of the questionnaire items was 0.725～1.000 except item 11（0.558）and item16 （0.443）.The internal consistency coefficient of the questionnaire was 0.820，internal consistency coefficient of each dimension was above 0.7.Every item score was positively correlated with corresponding dimension score（r=0.595～0.962）. Seven factors with latent roots greater than 1 could explain 76.3%of total variance，and these factors were relatively powerful in related items.Conclusions The medication dependence questionnaire in migraineurs of the Chinese version shows preferable reliability and validity.Thus，this is a promising assessment tool to evaluate the medication dependence in Chinese migraineurs in future clinical practice.

【Key Words】Migraine Medication dependence questionnaire in migraineurs of the Chinese version Reliability Validity

药物过度使用性头痛（medication-overuse headache，MOH）在世界范围内的发病率为0.9%～1.8%［1-3］。在头痛诊所或三级头痛中心，MOH患者已和偏头痛及紧张型头痛患者一样成为最大的头痛患者群体。在欧洲，MOH患者在头痛中心的比例高达20%，在美国这个比例甚至超过50%［4］。目前，国内尚无评估偏头痛患者药物依赖性的专门问卷。由Radat等［8］编制的法国版头痛患者药物依赖性问卷（Medication Dependence Questionnaire in Headache Patients，MDQ-H），总共分为7个维度，共21个问题。经检验后发现，其与精神疾病诊断与统计手册-4（The Diagnostic and Statistical Manual of Mental Disorders-Ⅳ，DSM-Ⅳ）中药物依赖综合征的诊断标准有较好的一致性，可作为临床上评估头痛患者药物依赖性的有效工具，但此问卷中文版的信度和效度尚未被检测。……