曹琳

[摘要] 目的 探讨复方小儿退热栓治疗小儿高热惊厥的可行性及安全性。 方法 选取2014年3月～2015年3月在我院就诊的120例高热惊厥的患儿作为研究对象，将其随机分为对照组和实验组，各60例。对照组采用抗感染基础治疗，给予地西泮注射液、口服苯巴比妥；实验组在对照组的基础上给予复方小儿退热栓。比较两组患儿的临床疗效及不良反应发生率。 结果 实验组总有效率为96.67%，明显高于对照组的81.67%，差异有统计学意义（P<0.05）。实验组总不良反应发生率为1.67%，明显低于对照组的18.33%，差异有统计学意义（P<0.05）。 结论 复方小儿退热栓治疗小儿高热惊厥的疗效显著，不良反应发生率低，安全有效，值得临床推广应用。

[关键词] 复方小儿退热栓；小儿高热惊厥；临床疗效；可行性；安全性

[中图分类号] R272.3 [文献标识码] A [文章编号] 1674-4721（2016）03（b）-0087-03

[Abstract] Objective To explore the feasibility and safety of compound pediatric antifebrile suppository in the treatment of children with febrile seizures. Methods 120 children with febrile seizures in our hospital from March 2014 to March 2015 were chosen as study objects and randomly divided into the control group and the experimental group，each group had 60 cases.The control group was treated with anti-infection basic treatment and was given diazepam injection，oral phenobarbital.The experimental group was added rectal administration of compound pediatric antifebrile suppository on the basis of the control group.The clinical efficacy and adverse reactions between two groups were compared. Results The total efficiency of the experimental group was 96.67%，which was higher than 81.67% in the control group，the difference was statistically significant（P<0.05）.The adverse reactions rate of the experimental group was 1.67%，which was lower than 18.33% in the control group，the difference was statistically significant（P<0.05）. Conclusion Compound pediatric antifebrile suppository is effective and safe in treating children with febrile seizures，the adverse reactions rate is low，which is suitable for clinical application.

[Key words] Compound pediatric antifebrile suppository；Children with febrile seizures；Feasibility；Safety

高热惊厥是小儿时期的多发症状，大多发生在婴幼儿急骤高热（体温达39～41.5℃）后的12 h内，临床特点表现为忽然短暂出现全身性惊厥症状、随后长时间抽搐[1]。小儿高热惊厥若无法得到有效控制，易导致大脑缺氧、脑细胞损害，患儿的智力发育及健康成长受到严重影响[2]，因此积极控制高热惊厥对于减轻小儿的脑损伤及预后具有重大意义[3]。近年来有研究表明，复方小儿退热栓具有显著镇静、退热及增强免疫力的疗效[4]，引起学者的广泛关注。本实验选取我院就诊的120例高热惊厥患儿作为研究对象，旨在探讨复方小儿退热栓治疗小儿高热惊厥的可行性及安全性。

1 资料与方法

1.1 一般资料

选取2014年3月～2015年3月在我院就诊的120例高热惊厥的患儿作为研究对象，经全面检查，所有患儿均确诊为伤风性感冒造成的发热，患儿先表现为发热，然后出现惊厥或两种症状同时出现。……