黄海波，黄桂雄*，陈毓秀，李大创，孙熙勇，管俊，覃明



肾脏磁共振梯度多回波-R2*成像可行性研究

黄海波1，黄桂雄1*，陈毓秀2，李大创1，孙熙勇3，管俊1，覃明1

[摘要]目的 探讨磁共振肾脏梯度多回波R2*成像可行性。材料与方法 应用3.0 T MR系统梯度多回波序列，分别扫描专用水模(含氯化锰盐酸混合液小瓶15只)、原位正常肾51例(A组)和移植正常肾22例(B组)志愿者，次月重复扫描专用水模、原位正常肾组，原始DICOM数据导入CMRtools软件测算获得水模各小瓶及肾皮髓质R2*值。结果 水模R2*与其浓度直线相关(r=0.999，P=0.000)，通过直线回归分析，得到R2*与PhC拟合直线斜率为0.008，截距为–0.050。实际与预测水模浓度组内相关系数(ICC)为0.999，重复扫描水模R2*ICC为1，重复扫描水模R2*差值与总体0比较无统计学意义(P＞0.05)。原位和移植肾组间性别与年龄无统计学意义(P＞0.05)；原位肾双侧R2*无统计学差异(P＞0.05)；原位肾皮髓质重复测量R2*ICC分别为0.847和0.915，差值与总体0无统计学意义(P＞0.05)。移植与原位正常肾R2*无统计学差异(P＞0.05)，肾髓质R2*显著高于皮质，差异有统计学意义(P＜0.05)。结论 磁共振梯度多回波R2*成像评价肾氧合状态具有可行性，可为更多肾脏R2*成像推广应用提供依据。

[关键词]肾脏；磁共振成像；诊断技术和方法

广西科学研究与技术开发计划项目(编号：桂科攻1298003-8-6)

作者单位：

1.解放军第303医院影像科，南宁，530021

2.武警陕西总队医院MR室，西安，710054

3.解放军第303医院移植科，南宁，530021

黄桂雄，E-mail: 303hgx@163.com

接受日期：2015-11-09

黄海波, 黄桂雄, 陈毓秀, 等.肾脏磁共振梯度多回波-R2*成像可行性研究.磁共振成像, 2016, 7(1): 62–67.

Feasibility of multiple-echo GRE-R2*to renals at 3.0 T MRI

Huang Hai-bo1, Huang Gui-xiong1*, Chen Yu-xiou2, Li Da-chuang1, Sun Xi-yong3, Guan Jun1, Qin Ming1

1Department of Medical Imaging, 303rd Hospital of PLA, Nanning 530021, China

2MR Room of Shanxi CAPF Hospital, Nanning 530003, China

3Department of Transplantation, 303rd Hospital of PLA, Nanning 530021, China

*Correspondence to: Huang GX, E-mail: 303hgx@163.com

Received 28 Sep 2015, Accepted 9 Nov 2015

ACKNOWLEDGMENTS Guangxi Scientific and Technological Plan (No.GUIKEGONG1298003-8-6).

Abstract Objective: To explore the feasibility of multiple-echo GRE- R2*to renals at 3.0 T MRI.Materials and Methods: A MR phantom which includes fifteen vials containing 0.2—3.2 mmol/L manganese chloride in hydrochloric acid solution, 51 healthy vonlunteers (Group A) with kidneys in-situ and 22 normal renals (Group B) transplanted were scanned by 3.0 T MRI, repeated protocols to the phantom and group A with kidneys in-situ one month later.Both phantom and in-vivo renals R2*were quantified by a well-trained physician using a CMR tools after MRI.Results: Phantom R2*was linearly correlated with its concentration in vials (r=0.999, P=0.000).Through the regressions procedure,a slope of 0.008 and an intercept of –0.050 were found.No statistic differences were found for R2*value between the first and second scanning on phantom (P＞0.05), The real and predicted concentration of phantom, R2*repeated scanning on phantom have a highly reliability respectively (ICCconcentration=1, ICCR2*=0.999).No statistic differences were found for gender and age between group A and B(P＞0.05).No statistic differences were found for the cortical and medullary R2*between left and right renal (P＞0.05).No statistic differences were found for kidneys R2*in group A between the first and second scanning (P＞0.05), It showed a well reliability respectively (ICCcortex=0.847, ICCmedullation=0.915).No statistic differences were found for renal R2*between group A and B (P＞0.05).However, renal R2*was dramatically higher in medullation than in cortex and there was statistic difference (P＜0.05).Conclusions: With CMRtools, multiple-echo GRE protocol is feasible for evaluating oxygenation in kidneys at 3.0 T MRI, it could provide a reliable evidence for clinic application to renals.

Key words Kidney; Magnetic resonance imaging; Diagnostic techniques and procedures

肾实质氧合状态在肾疾病发生、发展中具……