李超伟，鲍海华，孔德民，李伟霞，员强



基于体素形态学测量技术对高原地区正常成人脑结构的研究

李超伟，鲍海华*，孔德民，李伟霞，员强

[摘要]目的 基于体素形态学测量(VBM)技术，分析久居高原地区(＞3000 m) 正常成人脑结构体积的变化。材料与方法 选取两组正常成人参与本次研究，其中包括高原组[男8例，女8例，平均年龄(21.81 ± 2.07)岁]和与之年龄、受教育年限相匹配的平原组[男7例、女13例，平均年龄(21.85 ± 1.90)岁]，对每个被试行全脑扫描，获取3D-T1结构图像，利用VBM方法对全脑灰、白质图像进行统计学分析。结果 与平原组比较，高原组正常成人左侧后扣带回、颞上回灰质体积增加；右侧岛叶灰质体积减低；白质体积增加区域为左侧丘脑、右侧额上回、左侧豆状核、左侧枕叶。结论 利用VBM技术对MRI结构图像分析，能够客观显示高原地区相对平原地区正常成人脑部特定区域体积的变化，从而全面的评价高原长期低氧对脑结构的影响。

[关键词]脑；人体测量术；高原；磁共振成像

国家自然科学基金(编号：81060117)；青海省科技厅国际合作项目(编号：2012-H-807)

作者单位：

青海大学附属医院影像中心，西宁810001

鲍海华，E-mail: baohelen2@sina.com

接受日期：2015-11-11

李超伟, 鲍海华, 孔德民, 等.基于体素形态学测量技术对高原地区正常成人脑结构的研究.磁共振成像, 2016, 7(1): 1–5.

Study of brain structure in nomal plateau area adult with voxel-based morphometry

LI Chao-wei, BAO Hai-hua*, KONG De-min, Li Wei-xia, YUAN Qiang

The Affiliated Hospital of Qinghai University, Medical Imaging Center, Xining 810001, China

*Correspondence to: Bao HH, E-mail: baohelen2@sina.com

Received 17 Oct 2015, Accepted 11 Nov 2015

ACKNOWLEDGMENTS National Natural Science Foundation of China(No.81060117).International cooperation project of science and Technology Department of Qinghai Province (No.2012-H-807).

Abstract Objective: The aim of the study was to investigate the brain structure volumes alterations in born and raised high altitude (HA) (＞3000 m) normal adult by using voxel-based morphometry method (VBM).Materials and Methods: Two groups of adults participated in the study, including an HA group [8 males and 8 females, mean age=(21.81±2.07) years] and an age- and education-matched sea level (SL) group [7 males and 13 females, mean age=(21.85±1.90) years].3D-T1 structural images of all subjects who were underwent the whole brain scan were acquired.Then we used the VBM method to compare the whole brain GM and WM images differences between HA group and SL group.Results: HA acclimatization (vs.SL) showed increased gray matter volume in the left posterior cingulate, the left superior temporal gyrus,decreased GM volumes was found in the right insular lobe in highland group and we also found increased WM volumes in left thalamus, the right superior frontal gyrus, the lentiform nucleus, the left occipital lobe.Conclusions: The VBM method was applied to the analysis of the magnetic resonance structural images and it could objectively display the volume changes of specific brain areas in HA group and could get us a comprehensive evaluation of the impact of altitude hypoxia on brain structure.

Key words Brain; Anthropometry; Altitude; Magnetic resonance imaging

青藏高原号称“世界屋脊”，是我国面积最大，海拔最高，居住人口最多的高原地区。缺氧是高原环境影响人体的最关键的因素之一。近年来，有关高原低氧对脑部影响的文献报道比较多，例如对慢性高原病患者脑部的病理生理及神经影像学表现进展[1]做一综述；……