老年性高血压患者不同降压方案体位性低血压发生情况研究
2015-10-21代诗琼
代诗琼


摘要:目的:研究不同降压方案在老年性高血压患者治疗中体位性低血压的发生情况。方法:将老年高血压患者180例随机分为A、B、C组各60例,A组给予苯磺酸氨氯地平片治疗,B组给予厄贝沙坦片+氢氯噻嗪片治疗,C组给予苯磺酸氨氯地平片+氢氯噻嗪片+厄贝沙坦片治疗。结果: B组患者立卧位血压变化程度低于A组,C组患者立卧位血压变化程度低于A、B组,差异均有统计学意义(P<0.05)。C组体位性低血压发生率低于A组,差异有统计学意义(P<0.05);与B组比较差异无统计学意义(P>0.05)。结论:钙通道阻滞剂、血管紧张素Ⅱ受体拮抗剂、利尿剂联合应用治疗老年高血压,可降低体位性低血压的发生率,安全性高。
关键词:高血压,老年;降压药;体位性低血压
Abstract:Objective To study the occurrence of postural hypotension in different antihypertensive therapy for the elderly patients with hypertension. Methods The 180 elderly patients with hypertensive were randomly divided into A, B, C group of 60 cases, A group was given amlodipine besylate tablets treatment, B group was treated with Irbesartan tablets and hydrochlorothiazide tablets, C group was given amlodipine besylate tablets and hydrochlorothiazide tablets and Irbesartan tablets. Results The stand and supine position blood pressure change of B group patients was lower than that of A group, C group of that was less than A and B group, the differences were statistically significant (P<0.05). The incidence of postural hypotension of C group was lower than that of A group, the difference was statistically significant (P<0.05); there was no significant difference compared with B group (P>0.05). Conclusion Calcium channel blockers, angiotensin II receptor blockers, diuretics combined treatment in the elderly patients with hypertension, can reduce the incidence of postural,and high security.
Keywords: Hypertension, elderly; Blood pressure medication; Postural hypotension
高血压发病率高,多见于中老年人,如控制不佳可导致心脏病、脑卒中等多种疾病。降压过度时容易发生体位性低血压,亦可促进心脑血管意外事件的发生。本文旨在探讨不同降压方案在老年高血压患者治疗中体位性低血压的发生情况。现报道如下。
1 资料与方法
1.1 临床资料 选择2014年3月—2015年4月我科住院部收治的老年高血壓患者180例,均符合《中国高血压防治指南》中高血压诊断标准[1]。男99例,女81例;年龄61~79岁,平均(68.7±4.9)岁;病程3~16年,平均(8.6±2.5)年;合并症:高血压性心脏病21例,冠状动脉粥样硬化性心脏病15例,糖尿病18例,脂类代谢障碍性疾病11例;排除标准:继发性高血压、肝肾功能障碍、精神疾病等患者。所有患者随机分为A、B、C组各60例,3组患者性别、年龄、身高、体质量、血压、合并症等方面比较差异无统计学意义(P>0.05),具有可比性。
1.2 方法
1.2.1 药物治疗方法:所有患者治疗前2周停止服用血管紧张素Ⅱ受体拮抗剂(ARB)类、钙通道阻滞剂类、利尿剂类降压药物。A……
