脑梗死患者血清中ACA、hs—CRP和Hcy含量变化的关系研究
2015-08-29胡世坤
胡世坤

[摘要] 目的 探究脑梗死患者血清中ACA、hs-CRP及Hcy的含量变化。 方法 选取该院2012年5月—2014年5月收治的符合标准的脑梗死患者80例;另选正常对照组80例。分别检测其血清中ACA、hs-CRP及Hcy的含量,比较脑梗死组与正常对照组间的差异,并进行检验分析。结果 脑梗死组的ACA、hs-CRP及Hcy水平与正常对照组相比差异有统计学意义(P<0.05);脑梗死组的hs-CRP、ACA与Hcy水平相比较呈正相关性;正常对照组间无相关性。结论 脑梗死患者血清中ACA、hs-CRP及Hcy的含量变化是发生脑梗死的独立危险因素,三项指标联检有利于对脑梗死进行早期诊断与治疗。
[关键词] 脑梗死;同型半胱氨酸;ACA;hs-CRP
[中图分类号] R74 [文献标识码] A [文章编号] 1674-0742(2015)01(a)-0010-02
Study on the Relationship Between the Change of Content of Serum ACA and hs-CRP with That of Hcy in Patients with Cerebral Infarction
HU Shikun
Clinical Laboratory, Pingdingshan the Second People's Hospital, Pingdingshan, Henan Province, 467000, China
[Abstract] Objective To explore the changes of content of serum ACA, hs-CRP and Hcy in patients with cerebral infarction. Methods 80 patients with cerebral infarction met the standards of our hospital admitted from May 2012 to May 2014 were selected and other 80 cases were selected as the normal control group. The content of serum ACA, hs-CRP and Hcy was detected in the groups and the results were compared between the two groups and given a check analysis. Results There were significant differences in serum ACA, hs-CRP and Hcy levels between the cerebral infarction group and the normal control group(P<0.05); in the cerebral infarction group, the level of hs-CRP and ACA was positively correlated with that of Hcy; while in the normal control group, the level of hs-CRP and ACA was not correlated with the that of Hcy. Conclusion The content changes of serum ACA, hs-CRP and Hcy in patients with cerebral infarction are independent risk factors of cerebral infarction, and the combined detection of three indexes is conducive to the early diagnosis and treatment of cerebral infarction.
[Key words] Cerebral infarction; Homocysteine; ACA; hs-CRP
近些年来,随着人们生活水平的提高和工作压力的增多,人们羁患心脑血管疾病的概率逐年增多,特别是脑梗死的发病率,呈加速上升的趋势。目前,临床上对于脑梗死的发病机制尚未完全明确,且缺少创伤性脑梗死早期诊断与治疗的根据[1]。因此,该次研究对2012年5月—2014年5月收治的脑梗死患者的血清抗心磷脂抗体(ACA)、高敏C反应蛋白(hs-CRP)及同型半胱氨酸(Hcy)含量进行研究分析,并探讨脑梗死的发病机制与其关系,现报道如下。
1 资料与方法
1.1 一般资料
该院收治脑梗死患者80例,其中男性48例,女性32例,年龄33~73岁,平均年龄(55.5±17.3)岁;入选标准:符合全国第四届脑血管病学术会议制定的关于脑梗死的诊断标准[2],经颅脑CT、MRI等相关检查结合临床症状确诊为脑梗死。排除患者其他系统疾病史;另选取正常对照组80例,其中男性44例,女性36例,年龄32~66岁,平均年龄(45.5±15.3)岁。
1.2 标本采集
被检者2周内停用影响血液凝固及抗生素类等药物,于清晨空腹采血3 mL,在37 ℃水浴箱内静止30 min后给予3 500 r/min离心15 min,立即分离血清待检。
1.3 方法
采用ACA试剂盒,用酶联免疫吸附法进行测定;……
