杨石

[摘要] 目的 观察柳氮磺胺吡啶联合双歧三联活菌胶囊治疗轻中度溃疡性结肠炎的临床效果。 方法 将2012年6月～2014年6月在本院进行治疗的、已确诊的、符合纳入标准的106例轻中度溃疡性结肠炎患者随机分为观察组和对照组，每组53例。观察组采用柳氮磺吡啶，1.0 g/次，4次/d，口服；联合双歧杆菌三联活菌胶囊，0.63 g/次，3次/d，口服；两种药物服用时间间隔2 h。对照组单用柳氮磺吡啶，1.0 g/次，4次/d，口服。每周随访，治疗12周后进行效果评估。 结果 观察组排便次数、便血、内镜检查及医师总体评分均低于对照组，差异有统计学意义（P<0.01）；用改良Mayo评分比较，观察组疗效明显优于对照组，差异有统计学意义（P<0.01）。 结论 柳氮磺胺吡啶联合双歧三联活菌胶囊治疗溃疡性结肠炎，可有效提高治疗效果，改善患者的临床症状，减少复发，值得推广应用。

[关键词] 溃疡性结肠炎；柳氮磺胺吡啶；双歧三联活菌胶囊；改良Mayo评分

[中图分类号] R574.62 [文献标识码] A [文章编号] 1674-4721（2015）02（b）-0114-03

Efficacy observation of Salazosulfapyridine combined with bifid triple viable capsules in treatment of mild moderate ulcerative colitis

YANG Shi LIU Yun-yang YU Ying YAO Jia-ru

Qishi Hospital of Dongguan City in Guangdong Province，Dongguan 523500，China

[Abstract] Objective To observe the clinical effects of Salazosulfapyridine combined with bifid triple viable capsules in treatment of mild moderate ulcerative colitis. Methods 106 patients with mild moderate ulcerative colitis treated in our hospital from June 2012 to June 2014，confirmed and met the inclusion criteria were selected，and were randomly divided into observation group and control group，53 cases in each group.In observation group，Salazosulfapyridine （1.0 g per time，4 times a day，oral） combined with bifid triple viable capsules （0.63 g per time，3 times a day，oral） were applied，and the interval time between two medications was 2 hours；while in control group，only Salazosulfapyridine （1.0 g per time，4 times a day，oral） was applied.Weekly follow-up was elaborated during the clinical process.After 12 weeks the treatment，the efficacy was compared. Results The defecation frequency，hemafecia condition，endoscopic examination and overall physician ratings in observation group was lower than that in control group，the differnece was significant （P<0.01）.According to modified Mayo score，the treatment effect of observation group was superior than that of control group，the differnece was significant （P<0.01）. Conclusion Salazosulfapyridine combined with bifid triple viable capsules in treatment of mild moderate ulcerative colitis can improve the clinical effect，mitigate clinical symptoms of patients，reduce the probability of recurrence，and is worthy of further promotion and application.

[Key words] Ulcerative colitis；Salazosulfapyridine；Bifid triple viable capsules；Modified Mayo score

溃疡性结肠炎是一种病因尚不十分清楚的结肠和直肠慢性非特异性炎症性疾病，病变局限于大肠黏膜及黏膜下层，多位于乙状结肠和直肠，也可延伸至降结肠，甚至整个结肠，临床表现主要包括腹痛、腹泻和黏液脓血便，还可合并胃肠道外表现，如皮肤损害、关节炎等，其病程漫长，常反复发作。根据《炎症性肠病诊断与治疗的共识意见》（2012·广州）治疗轻中度溃疡性结肠炎仍首选氨基水杨酸制剂，包括传统的柳氮磺胺吡啶和其他各种不同类型的5-氨基水杨酸制剂[1]，本文采用柳氮磺胺吡啶联合双歧三联合活菌胶囊治疗轻中度溃疡性结肠炎，观察其临床效果。