张利亚++郑爱文

[摘要] 目的 观察临床中卵巢癌合并腹腔积液患者应用热灌注化疗的临床疗效。方法 选取我院2006年1月～2013年1月期间40例卵巢癌合并腹腔积液患者为研究对象，按照随机数字法分为研究组和对照组各20例。所有病例都曾经手术治疗，病理确诊为上皮性卵巢癌，均行术后化疗，肿瘤未控或复发，合并腹腔积液。对照组给予常规全身化疗，研究组给予腹腔热灌注化疗联合全身化疗，观察两组临床疗效。结果 研究组治疗有效率和生活质量评分均明显高于对照组（P<0.05），差异有统计学意义；两组患者均未发生严重的毒副反应，出现毒副反应较轻，均对症处理后缓解。研究组1年生存率为85.0%，对照组为65.0%，差异有统计学意义（P<0.05）。 结论 对于卵巢癌合并腹腔积液患者给予热灌注化疗治疗是可行的，能有效提高临床疗效与生活质量，值得临床应用。

[关键词] 卵巢癌；腹腔积液；热灌注化疗；临床疗效

[中图分类号] R737.31 [文献标识码] B [文章编号] 1673-9701（2014）29-0146-03

Efficacy observation of chemohyperthermia in treatment of ovarian cancer combined with peritoneal effusion

ZHANG Liya1 ZHENG Aiwen2

1.Department of Obstetrics and Gynecology， Haining Hospital of Traditional Chinese Medicine in Zhejiang Province， Haining 314400，China；2. Department of Gynecologic Oncology， Zhejiang Cancer Hospital， Hangzhou 310022，China

[Abstract] Objective To observe the clinical efficacy of chemohyperthermia in the treatment of ovarian cancer combined with peritoneal effusion. Methods Forty patients with ovarian cancer combined with peritoneal effusion treated in our hospital from January 2006 to January 2013 were selected as the study subjects and randomly divided into the study group and the control group according to the random number method， with 20 patients in each group. All the patients once went through surgical treatment， were diagnosed with epithelial ovarian cancer， received postoperative chemotherapy， had uncontrolled or recurrent tumor， and were complicated by peritoneal effusion. The control group was given conventional whole body chemotherapy and the study group was given intraperitoneal chemohyperthermia combined with whole body chemotherapy. The clinical efficacy of the two groups was observed. Results The study group had significantly higher treatment effective rate and life quality score than the control group （P<0.05）， with statistical significance. Neither group had severe toxic nor side reactions； The existing toxic and side reactions were mild and remitted after symptomatic treatment. The 1-year survival rate of the study group was 85.0% and that of the control group was 65.0%. The study group had significantly higher 1-year survival rate than the control group （P<0.05）， with statistical significance. Conclusion It is feasible to provide chemohyperthermia to the patients with ovarian cancer combined with peritoneal effusion and it can effectively improve the clinical efficacy and life quality， which is worthy of clinical application.endprint

[Key words] Ovarian cancer； Peritoneal effusion； Chemohyperthermia； Clinical efficacy

卵巢癌是妇科中比较常见的恶性疾病，尽管发病率位于子宫颈癌和子宫内膜癌之后，但其死亡率一直居女性生殖道恶性肿瘤的首位。由于卵巢深居盆腔，出现症状较晚，临床中多数患者就诊时已经属于中晚期[1]。尽管大部分患者经过手术治疗及化疗，但仍有很多患者失败于盆腹腔复发或转移。为缓解患者的痛苦，进一步提高其生活质量[2]，我们对复发或未控的上皮性卵巢癌合并腹腔积液患者应用热灌注化疗联合全身化疗，取得了较好的应用效果，现报道如下。

1资料与方法

1.1临床资料

选取我院2006年1月～2013年1月期间40例卵巢癌合并腹腔积液患者为研究对象，按照随机数字法分为研究组和对照组各20例。研究组的年龄38～77岁，平均（54.2±4.1）岁；Ⅲ期12例，Ⅳ期8例；浆液性癌11例，黏液性癌7例，未分化癌2例。对照组的年龄39～79岁，平均（55.2±3.3）岁；……