罗丽娟+万盛华+许增华

[摘要] 目的 探讨奥美拉唑治疗小儿消化性溃疡的临床效果。 方法 选取100例消化性溃疡患儿作为研究对象，随机分为研究组与对照组，每组50例，两组均给予阿莫西林、克拉霉素治疗，在此基础上，研究组给予奥美拉唑治疗，对照组给予西咪替丁治疗，比较两组的治疗效果。 结果 研究组的治疗效果显著优于对照组，差异有统计学意义（P<0.05）；研究组的Hp根治效果显著优于对照组，差异有统计学意义（P<0.05）。两组的并发症或不良反应发生情况比较，差异无统计学意义（P>0.05）。 结论 奥美拉唑治疗小儿消化性溃疡效果显著，安全性好，值得临床推广应用。

[关键词] 小儿；消化性溃疡；奥美拉唑；临床疗效

[中图分类号] R573.1 [文献标识码] A [文章编号] 1674-4721（2014）09（b）-0099-03

Effect observation of omeprazole in the treatment of pediatric peptic ulcer

LUO Li-juan WAN Sheng-hua XU Zeng-hua

Department of Gastroenterology，Children′s Hospital in Jiangxi Province，Nanchang 330006，China

[Abstract] Objective To explore clinical effect of omeprazole in the treatment of pediatric peptic ulcer. Methods 100 cases with peptic ulcer were selected as research subjects，and the patients were randomly divided into research group and control group，50 cases in each group.All these participants were treated with amoxicillin and clarithromycin，on this basis，the research group was treated with omeprazole，and the control group was treated with cimetidine，the treatment effect of two groups was compared respectively. Results The treatment effect in the research group is better than that in control group，with statistical significance（P<0.05），Hp eradication effect in research group is obviously better than that in control group，with statistical significance （P<0.05）.There was no statistical significance in complications or adverse situation between two groups （P>0.05）. Conclusion Omeprazole in the treatment of pediatric peptic ulcer has significant efficacy and superior safety，and it is worthy of clinical promotion and application.

[Key words] Children；Peptic ulcer；Omeprazole；Clinical efficacy

奥美拉唑是一种见效快、应用十分广泛的质子泵抑制剂，可选择性的作用于胃黏膜壁细胞，进而抑制胃酸分泌[1]，还可抑制胃壁细胞中H+-K+-ATP酶活性，对消化性溃疡具有显著疗效。小儿消化性溃疡多急性发病，上消化道出血为其首发症状，分为原发性和继发性。因早期临床症状具有非典型性[2]，诊断难度较大。随着电子胃镜检查技术的推广应用，小儿消化性溃疡临床检出率明显提升，其临床治疗方法的相关研究工作也在不断推进。本研究选取本院2012年4月～2013年12月收治的100例消化性溃疡患儿作为研究对象，探讨奥美拉唑治疗小儿消化性溃疡的临床效果。

1 资料与方法

1.1 一般资料

选取本院2012年4月～2013年12月收治的100例消化性溃疡患儿作为研究对象，患儿均伴有腹痛、腹胀、反酸、嗳气、上消化道出血等临床症状，经内镜检查发现溃疡面（直径0.3～2.0 cm），经胃黏膜活检及13C-尿素呼气实验提示幽门螺旋杆菌（Helicobacter pylori，Hp）阳性。……