冉晓蓉 文昌晖 张莹雪

[摘 要]目的 分析对玫瑰痤疮患者采用凉血五花汤加减联合染料激光治疗的效果。方法 选取2023年1月-2024年1月贵州中医药大学第一附属医院收治的76例玫瑰痤疮患者为研究对象，随机分为对照组和观察组，每组38例。对照组给予凉血五花汤加减治疗，观察组给予凉血五花汤加减联合染料激光治疗，比较两组皮损恢复情况、中医证候积分及不良反应发生情况。结果 观察组治疗后皮损评分低于对照组，差异有统计学意义（P<0.05）；观察组治疗后红斑、干燥、丘疹、疼痛、皮肤潮红、瘙痒积分均低于对照组，差异有统计学意义（P<0.05）；观察组不良反应发生率为2.63%，低于对照组的18.42%，差异有统计学意义（P<0.05）。结论 凉血五花汤加减联合染料激光治疗玫瑰痤疮的临床效果良好，能够有效促进皮损恢复，改善痤疮症状，且治疗后不良反应发生几率较低，安全性较高，为玫瑰痤疮的治疗提供了新思路、新方法。

[关键词] 玫瑰痤疮；凉血五花汤加减；染料激光；中医证候积分

[中图分类号] R758.73+3 [文献标识码] A [文章编号] 1004-4949（2024）10-0039-04

Clinical Effect of Modified Liangxue Wuhua Decoction Combined with Dye Laser in the Treatment of Rosacea

RAN Xiao-rong1， WEN Chang-hui2， ZHANG Ying-xue1

（1.The First Clinical Medical College of Guizhou University of Traditional Chinese Medicine， Guiyang 550001， Guizhou， China； 2.The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine， Guiyang 550001， Guizhou， China）

[Abstract]Objective To analyze the effect of Liangxue Wuhua decoction combined with dye laser in the treatment of rosacea. Methods A total of 76 patients with rosacea admitted to the First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine from January 2023 to January 2024 were randomly divided into control group and observation group， with 38 patients in each group. The control group was treated with modified Liangxue Wuhua decoction， and the observation group was treated with modified Liangxue Wuhua decoction combined with dye laser. The recovery of skin lesions， TCM syndrome scores and adverse reactions were compared between the two groups. Results After treatment， the skin lesion score of the observation group was lower than that of the control group， and the difference was statistically significant （P<0.05）. After treatment， the scores of erythema， dryness， papules， pain， skin flushing and pruritus in the observation group were lower than those in the control group， the differences were statistically significant （P<0.05）. The incidence of adverse reactions in the observation group was 2.63%， which was lower than 18.42% in the control group， and the difference was statistically significant （P<0.05）. Conclusion The clinical effect of Liangxue Wuhua decoction combined with dye laser in the treatment of rosacea is good. It can effectively promote the recovery of skin lesions and improve the symptoms of acne. Meanwhile， the incidence of adverse reactions after treatment is low and the safety is high， which provides new ideas and new methods for the treatment of rosacea.

[Key words] Rosacea； Liangxue wuhua decoction； Dye laser； TCM syndrome scores

玫瑰痤疮（rosacea）是临床常见的皮肤疾病，会给患者的外观和心理带来严重不良影响[1]。近年来，临床治疗玫瑰痤疮的方法有很多种，如外用药物、口服药物等，但治疗效果不佳，且药物治疗存在一定的副作用。因此，针对玫瑰痤疮临床还需探索更有效的治疗手段。染料激光治疗是一种非侵入性治疗手段，能够针对性地破坏病变血管，减少红斑和炎症。凉血五花汤加减方作为中医药方，具有清热凉血、祛风通络的作用，被广泛应用于玫瑰痤疮的治疗中，可有效降低皮肤炎症反应，减少局部红肿、疼痛[2]。但目前关于两者联用效果的相关研究较少。基于此，本研究结合2023年1月-2024年1月贵州中医药大学第一附属医院收治的76例玫瑰痤疮患者临床资料，旨在探究凉血五花汤加减联合染料激光治疗玫瑰痤疮的临床效果，现报道如下。……