朱秀丽 张肖平

[摘 要]目的 探究微针导入伯纳赫胶原凝胶联合果酸治疗黄褐斑的效果。方法 选取我院2020年1月-2022年10月收治的56例黄褐斑患者为研究对象，采用随机数字表法分为对照组和观察组，各28例。对照组采用单一果酸治疗，观察组采用微针导入伯纳赫胶原凝胶联合果酸治疗，比较两组临床疗效、皮损面积及严重程度、满意度、不良反应发生情况。结果 观察组治疗总有效率为96.43%，高于对照组的67.86%（P<0.05）；观察组治疗后1、2、3个月MASI评分均低于对照组（P<0.05）；观察组总满意度为100.00%，高于对照组的71.43%（P<0.05）；观察组不良反应发生率为10.71%，高于对照组的7.14%，但差异无统计学意义（P>0.05）。结论 对黄褐斑患者应用微针导入伯纳赫胶原凝胶联合果酸治疗，可减轻患者的临床症状，改善其皮损面积及严重程度，进而提升患者满意度，值得临床应用。

[关键词] 微针导入；伯纳赫胶原凝胶；果酸；黄褐斑

[中图分类号] R758.4+2 [文献标识码] A [文章编号] 1004-4949（2024）10-0036-03

Clinical Effect of Microneedle Introduction of Bonneheure Collagen Gel Combined with Glycolic Acid in the Treatment of Chloasma

ZHU Xiu-li， ZHANG Xiao-ping

（Dermatology Department of Traditional Chinese Medicine Dermatology Hospital， Yantai Academy of Agricultural Sciences， Yantai 265500， Shandong， China）

[Abstract]Objective To explore the effect of microneedle introduction of Bonneheure collagen gel combined with glycolic acid in the treatment of chloasma. Methods A total of 56 patients with chloasma admitted to our hospital from January 2020 to October 2022 were selected as the research objects. They were divided into control group and observation group by random number table method， with 28 patients in each group. The control group was treated with single glycolic acid， and the observation group was treated with microneedle introduction of Bonneheure collagen gel combined with glycolic acid. The clinical efficacy， skin lesion area and severity， satisfaction and adverse reactions were compared between the two groups. Results The total effective rate of treatment in the observation group was 96.43%， which was higher than 67.86% in the control group （P<0.05）. The MASI score of the observation group at 1， 2 and 3 months after treatment was lower than that of the control group （P<0.05）. The total satisfaction rate of the observation group was 100.00%， which was higher than 71.43% of the control group （P<0.05）. The incidence of adverse reactions in the observation group was 10.71%， which was higher than 7.14% in the control group， but difference was not statistically significant （P>0.05）. Conclusion The application of microneedle introduction of Bonneheure collagen gel combined with glycolic acid in patients with chloasma can reduce the clinical symptoms of patients， improve the area and severity of skin lesions， and then improve patient satisfaction， which is worthy of clinical application.

[Key words] Microneedle introduction； Bonneheure collagen gel； Glycolic acid； Chloasma

黄褐斑（chloasma）是一种慢性、获得性面部色素增加性皮肤病，临床表现为深浅不一、边界不清的淡褐色或深褐色斑片，对称分布于面颊、前额及下颌[1]。目前临床上对黄褐斑的治疗方式较多，包括药物治疗、光电治疗等。果酸作为治疗黄褐斑的常用药物，能加快角质细胞及少部分上层细胞的更新速度，在促进老化角质层脱落方面有较好的效果，但单纯应用果酸治疗效果欠佳[2]。有研究发现[3]，伯纳赫胶原凝胶可有效修复皮肤屏障，治疗黄褐斑的效果确切。基于此，本研究结合我院2020年1月-2022年10月收治的56例黄褐斑患者临床资料，旨在研究微针导入伯纳赫胶原凝胶联合果酸治疗黄褐斑的效果，现报道如下。

1 资料与方法

1.1 一般资料 选取烟台市农科院中医皮肤病医院2020年1月-2022年10月收治的56例黄褐斑患者为研究对象，采用随机数字表法分为对照组和观察组，各28例，均为女性。……