孙亭 张军 童萍 董丽平

摘要：目的 探讨血清补体蛋白C1q是否参与抑郁症的发病过程，从而对抑郁症的诊断提供临床参考。方法 选择扬州市苏北人民医院心理科确诊的抑郁症患者166例，同期选择在本院健康体检的正常人166例作为正常对照组，检测血清C1q。患者入院时以汉密尔顿抑郁量表（HAMD）评估患者的抑郁症状。结果 抑郁症组血清补体C1q高于对照组，差异有统计学意义（P <0.05），抑郁症患者补体C1q升高和年龄、性别存在相关性（P<0.05），抑郁症血清补体升高与阻滞相关，且成负相关（P<0.05）。结论 抑郁症患者血清补体C1q水平较正常对照组升高，男性抑郁障碍患者年龄越大补体升高越明显，这可能对抑郁症的诊断及病因学的探讨具有一定的临床意义。

关键词：补体 C1q  抑郁症 诊断

【Abstract】Objective Explore whether complement C1q is involved in the pathogenesis of depression， so as to provide clinical reference for the diagnosis of depression Methods Participants were recruited from Northern Jiangsu People's Hospital， including 166 patients with depression， and 166 physical examinees from Physical Examination Department（control group）. Comparisons of Serum C1q were made between the control group and case group. Depressive symptoms were assessed by the Hamilton Depression Scale at admission. Results The serum C1q of the depression group was higher than that of the control group， and the difference was statistically significant （P< 0.05）. The increase of complement C1q in patients with depression was correlated with age and gender （P < 0.05）. The increase of serum complement in patients with depression was correlated with block， and negatively correlated with block （P < 0.05）. Conclusion The level of serum complement C1q in patients with depression was higher than that in the normal control group， and the increase of complement in male patients with depression was more obvious with the older age， which may have certain clinical significance for the diagnosis and etiology of depression.

【Key words】 complement  C1q  Depression  diagnosis

【中图分类号】R749.4+1             【文献标识码】A             【文章编号】2107-2306（2021）09--02

抑郁症有明显的高自杀率和高致残率，已成为全世界疾病负担的主要原因之一，目前抑郁症的发病病因并不明确。补体分子C1q是经典补体级联的起始蛋白，参与抗原抗体复合物的清除，提高机体免疫力，抑制炎性反應等。目前血清补体C1q与精神疾病的关系越来越引起人们的关注，有研究发现双相情感障碍患者补体C1q降低 [1]。同时越来越多的证据表明炎症反应参与抑郁症的发病过程[2]，而补体C1q作为参与炎症反应的重要因子，可能参与抑郁症的发病机制。目前由于尚未发现特异性的遗传生物学、生物化学、神经病理改变作为客观的生物学指标，在缺乏生物标志物的情况下，目前的诊断依赖于临床评估，治疗在很大程度上是经验主义的[3]。……