刘美　穆晓驰

[摘要]目的：觀察双波长强脉冲光（Intense pulsed light，IPL）联合30%超分子水杨酸治疗面部寻常痤疮的有效性及安全性。方法：按照随机数字表法将2019年1月-12月笔者医院收治的60例寻常痤疮患者分为对照组与观察组，每组30例。对照组采用0.1%阿达帕林凝胶治疗，观察组采用双波长IPL联合30%超分子水杨酸治疗。两组均治疗12周，治疗后观察两组炎性皮损及痤疮红斑的治疗有效率、VISIA评分及不良反应。结果：治疗后，观察组的炎性皮损（86.67% vs 33.33%）及痤疮红斑（70.00% vs 23.33%）治疗有效率均明显高于对照组（P<0.05）。治疗后，两组的红斑、毛孔及紫质VISIA评分均较治疗前明显降低（P<0.05），观察组的红斑及毛孔VISIA评分均明显低于对照组（P<0.05）。两组不良反应发生率比较均无统计学差异（P>0.05）。结论：双波长IPL联合30%超分子水杨酸治疗面部寻常痤疮安全、有效，能够明显改善炎性皮损及痤疮红斑。

[关键词]寻常痤疮;痤疮红斑;炎性皮损;双波长强脉冲光;超分子水杨酸

[中图分类号]R758.73+3    [文献标志码]A    [文章编号]1008-6455（2021）09-0096-03

Clinical Evaluation of Double Wavelength Intense Pulsed Light Combined with 30% Supramolecular Salicylic Acid in the Treatment of Facial Acne

LIU Mei1， MU Xiao-chi2

（1.Department of Cosmetology， Affiliated Hospital of Liaoning University of Traditional Chinese Medicine，Shenyang 110032，Liaoning，China; 2. Department of Cosmetology， Technical Director of Hunnan Li Miao Medical Cosmetology Clinic，Shenyang 110000，Liaoning，China）

Abstract：Objective To observe the efficacy and safety of double wavelength intensive pulsed light （IPL） combined with 30% supramolecular salicylic acid in the treatment of facial acne. Methods  According to the random number table method， 60 patients with acne vulgaris who were divided into control group and observation group in our hospital from January to December 2019， with 30 patients in each group. Patients in the control group were treated with 0.1% adapalin gel， while patients in the observation group were treated with dual wavelength IPL combined with 30% supramolecular salicylic acid for 12 weeks. The effective rate of inflammatory skin lesions and acne erythema， VISIA score and adverse reactions were observed in the 2 groups. Results The effective rate of inflammatory skin lesions （86.67% vs 33.33%） and acne erythema （70.00% vs 23.33%） in the observation group was significantly higher than that in the control group （P<0.05）. After treatment， the VISIA score of erythema， pore and purple in both groups were significantly lower than that before treatment （P<0.05）. The VISIA score of erythema and pore in the observation group was significantly lower than that in the control group （P<0.05）. There was no significant difference in the incidence of adverse reactions between the two groups （P>0.05）.  Conclusion Dual wavelength IPL combined with 30% supramolecular salicylic acid was safe and effective in the treatment of facial acne， and could significantly improve inflammatory skin lesions and acne erythra.

Key words：facial acne; acne erythema; inflammatory skin lesions; double wavelength intensive pulsed light; supramolecular salicylic acid

寻常痤疮是发生在毛囊皮脂腺的一种慢性炎症性皮肤病，主要好发于青少年，对其心理和社交影响很大。临床表现以好发于面部的粉刺、丘疹、脓疱、结节等多形性皮损为特点[1]。寻常痤疮炎症治疗后遗留的红斑可持续数月，称为痤疮红斑[2]。单纯药物治疗对部分寻常痤疮效果不理想，特别是对痤疮红斑疗效比较差。寻求一种安全有效的治疗寻常痤疮并减少痤疮红斑的方法是皮肤科领域的研究方向之一。筆者科室采用双波长强脉冲光联合30%超分子水杨酸治疗面部寻常痤疮，效果满意，现报道如下。

1  资料和方法

1.1 一般资料：选择2019年1月-12月笔者医院收治的60例寻常痤疮患者为研究对象。入选标准：①符合《中国寻常痤疮治疗指南（2014年修订版）》中关于寻常痤疮的诊断标准;②Pillsbury寻常痤疮分级为Ⅱ、Ⅲ级;③年龄>18岁。排……