魏云强 何荣平 吕静 李灵颖 王明 王孝林 魏艾玲 何渝煦

【摘要】目的：通過探讨失眠内治方剂的用药规律，为临床用药提供参考。方法：规范化统计《中医方剂大辞典》中失眠使用中药的情况，并分别查出其所属类别、功效、药性、药味及归经，运用Excel 2016、SPSS 25.0、Weka 3.8等对得到的数据进行统计分析。结果：共筛选纳入失眠内治方剂58首，用药98味，高频使用中药有人参、甘草、酸枣仁、当归、茯苓、远志等16味药，多属补虚药、安神药、清热药、化痰止咳平喘药等，药性以甘、苦、辛、酸为主兼有淡、咸、涩药，药物归经中，以心、肺、脾、肾归经频次居多。根据高频中药的关联规则分析，得到药对配伍规则如酸枣仁-人参、茯苓-人参、麦冬-酸枣仁、茯神-酸枣仁、远志-人参、远志-酸枣仁、白芍-当归、生地黄-当归等。结论：数据挖掘结果发现失眠在临床上以虚证较为常见，治疗呈现以和阴阳，调气血，安五脏为主的用药特点，为失眠的临床治疗和研究提供一定参考依据。

【关键词】中医方剂大辞典;失眠;数据挖掘;用药规律

【中图分类号】R289 【文献标志码】 A 【文章编号】1007-8517（2021）23-0019-07

Analysis on the Medication Law of Lnsomnia Prescription in the

Great Dictionary of Traditional Chinese Medicine Prescription

WEI Yunqiang¹HE Rongping¹LYU Jing¹LI Lingying¹WANG Ming¹WANG Xiaolin¹WEI Ailing¹HE Yuxu^2*

1.Yunnan University of Chinese Medicine，Kunming 650500，China;

2.The First Affiliated Hospital of Yunnan University of Chinese Medicine/Yunnan

Provincial Hospital of Traditional Chinese Medicine ，Kunming 650021，China

Abstract：Objective  The purpose of this study is to explore the medication rule of internal prescription for insomnia in order to provide reference for doctors to use drugs in clinic. Methods  Standardized statistics of the use of traditional Chinese medicine in insomnia in the Great Dictionary of traditional Chinese Medicine prescriptions， and found out its category， efficacy， medicinal properties， medicine taste and meridian tropism respectively. Excel 2016， SPSS 25.0， Weka 3.8 were used to analyze the data. Results  A total of 58 prescriptions for internal treatment of insomnia were selected and 98 drugs were used. 16 medicines such as ginseng， licorice， sour jujube kernel， Angelica sinensis， Poria cocos， Polygala， etc. were selected and included in the internal treatment of insomnia， including ginseng， licorice， sour jujube kernel， Angelica sinensis， Poria cocos， Polygala， etc.， which were mostly used to tonify deficiency， calming nerves， clearing heat， resolving phlegm， relieving cough and asthma， etc.， mainly sweet， bitter， bitter， acid and light， salty and astringent drugs. According to the analysis of association rules of high-frequency traditional Chinese medicine， the compatibility rules of medicine pairs were obtained， such as wild jujube kernel-ginseng， Poria cocos-ginseng， Ophiopogon-sour jujube seed， Poria god-sour jujube seed， Polygala-sour jujube seed， Radix Paeoniae Alba-Angelica， Radix Rehmanniae-Angelica and so on. Conclusion  According to the results of data mining， it is found that the deficiency syndrome of insomnia is more common in clinic， so the treatment is mainly characterized by harmonizing yin and yang， regulating qi and blood， and calming the five internal organs， which provides a reliable reference for the clinical treatment and research of insomnia.

Key words：Great Dictionary of Traditional Chinese Medicine Prescriptions; Lnsomnia; Data Mining; Medication Rules

失眠是指主观上虽有适宜的睡眠时间和睡眠环境，但仍不满足于睡眠时间和/或睡眠质量，影响白天的社会功能。主要症状为睡眠困难（睡眠潜伏期>30 min）、睡眠维持障碍（整晚醒来次数>2次）、总睡眠时间（一般<6.5 h）、早醒、睡眠质量下降，同时伴有疲劳、抑郁或易怒、认知障碍等的日间功能障碍^[1]。据世界卫生组织统计，全球睡眠障碍的发病率为27%。根据中国睡眠研究会2016年发布的数据显示，有3亿多中国人患有睡眠障碍，中国成年人失眠的发病率多达38.2%，而且这一数据还在逐年增加^[2]。随着……