吴奇明　　黄玉梅

[关键词] 慢阻肺;噻托溴铵粉;多索茶碱;肺功能

[中图分类号] R563          [文献标识码] B          [文章编号] 1673-9701（2021）16-0064-04

Effect evaluation of doxofylline combined with tiotropium bromide powder in treatment of chronic obstructive pulmonary disease （COPD）

WU Qiming   HUANG Yumei

Department of Respiratory Medicine， The Fifth People′s Hospital of Ganzhou， Ganzhou   341000，China

[Abstract] Objective To analyze the effect of doxofylline combined with tiotropium bromide powder in the treatment of COPD. Methods Eighty-two patients with COPD treated in our hospital from January 2018 to December 2019 were selected as research subjects， and were divided into the observation group （n=41） and the control group （n=41） according to the treatment order. Doxofylline combined with tiotropium bromide powder was given to the observation group， and doxofylline single treatment was given to the control group. The changes of lung function indices， the treatment effects and the incidence rates of adverse reactions in the two groups were compared. Results Before the treatment， there were no significant differences in FEV1， FVC or FEV1/FVC between the two groups （P>0.05）. After the treatment， FEV1， FVC and FEV1/FVC in the observation group were higher than those in the control group， with significant differences（P<0.05）. The response rate in the observation group （95.12%） was higher than that in the control group （78.04%）， with significant difference （P<0.05）. The incidence rate of adverse reactions in the observation group （4.87%） was lower than that in the control group （9.76%）， without significant difference （P>0.05）. The scores of emotional function， physiological function， social function， body pain， mental health， vitality， physiological function and overall health in the observation group were higher than those in the control group， with significant differences （P<0.05）. Conclusion   In the treatment of COPD， doxofylline combined with tiotropium bromide powder can improve the lung function， maintain reasonable indexes of blood gas analysis， reduce the incidence rate of adverse reactions， and elevate the overall response rate， which has meaning for clinical practice.

[Key words] Chronic obstructive pulmonary disease; Tiotropium bromide powder; Doxofylline; Lung function

慢性阻塞性肺疾病（简称慢阻肺，COPD）是一种肺部疾病，属于常见的疾病类型，该疾病具有较长的病程时间，主要发病群体为中老年患者，该疾病具有较高的发病率，严重情况下，会引发死亡，由此可见，该疾病会危害到人体。其相关影响因素包括吸烟、环境及自身职业[1-2]。若有有害气体进入患者体内，会出现较多的粉尘、颗粒，引发慢阻肺疾病，咳嗽咳痰、气短、胸闷、喘息为患者常见的临床表现，已经被列为高危疾病的前几名，应采取有效措施，改善患者肺功能水平，加快患者疾病恢复速度，提升治疗总有效率，避免因治疗不及时，威胁到患者的生命安全[3]。本研究针对慢阻肺治疗中聯合应用噻托溴铵粉与多索茶碱的效果进行探讨，现报道如下。

1资料与方法

1.1 临床资料

本次试验研究对象是我院收治的82例慢阻肺患者，研究时段为2018年1月至2019年12月，按照患者就诊先后顺序将其分为两组，每组各41例。纳入标准：（1）本研究经伦理委员会批准。（2）所有患者对本次试验均知情，并自愿签署知情同意书。（3）入院前3 d所有患者未服用茶碱类及B2受体激动剂。（4）经检查，所有患者均符合慢阻肺诊断标准，且在不同程度上伴有上腹胀满、食欲减退、咳嗽、咳痰等症状[4]。排除标准：（1）治疗依从性较差患者。（2）伴有急性呼吸衰竭、糖尿病、恶性肿瘤患者。（3）伴有严重系统疾病及神志改变患者。（4）存在精神疾病……