张文凯

[摘要]目的分析子癇前期患者采用拉贝洛尔以及硫酸镁干预效果。方法对2019年10月至2020年12月湖北省妇幼保健院收治的84例子痫前期患者开展研究，依据随机数字表法将其分成常规组（ n=42）及试验组（ n=42），其中常规组患者使用硫酸镁及乌拉地尔进行干预，试验组患者则使用硫酸镁、乌拉地尔及拉贝洛尔进行干预。比较每组患者干预前后血压水平、心率水平、24 h 尿蛋白水平及血清尿酸水平，不良分娩结局发生率，新生儿不良结局发生率。结果干预后试验组舒张压及收缩压均低于常规组（ P <0.05）。干预后试验组24 h 尿蛋白及血清尿酸均低于常规组（ P <0.05）。试验组不良分娩结局总发生率为7.14%，明显低于常规组的38.10%（ P <0.05）。试验组新生儿不良结局总发生率为7.14%，显著低于常规组的23.81%（ P <0.05）。结论子痫前期患者使用拉贝洛尔及硫酸镁干预，可有效控制血压水平，降低24 h 尿蛋白及血清尿酸水平，改善不良分娩结局及新生儿结局，发挥一定干预作用。

[关键词]分娩结局;子痫前期;拉贝洛尔;硫酸镁;胎儿窘迫

[中图分类号] R714.24+4  [文献标识码] A   [文章编号]2095-0616（2021）23-0120-04

Clinical effect of magnesium sulfate combined with labetalol on preeclampsia and its influence on delivery outcome

ZHANG  Wenkai

Maternal and Child Health Hospital of Hubei Province， Hubei， Wuhan 430070， China

[Abstract] Objective To analyze the intervention effect of labetalol and magnesium sulfate in preeclampsia patients. Methods A total of 84 female patients with preeclampsia in Maternal and Child Health Hospital of Hubei Province were studied from October 2019 to December 2020. They were divided into the conventional group （n=42） and the experimental group （n=42） according to the random number table method. The patients in the conventional group were intervened with magnesium sulfate and urapidil， while those in the experimental group were intervened with magnesium sulfate， urapidil and labetalol. The blood pressure， heart rate， 24-hour urine protein and serum uric acid before and after intervention in each group were compared. The incidence of adverse delivery outcomes and incidence of adverse outcomes in newborns were recorded. Results After intervention， the diastolic blood pressure and systolic blood pressure in the experimental group were lower than those in the conventional group （P <0.05）. After intervention， the 24-hour urine protein and serum uric acid in the experimental group were lower than those in the conventional group （P <0.05）. The total incidence of adverse delivery outcomes in the experimental group was 7.14%， which was significantly lower than that in the conventional group （38.10%， P <0.05）. The total incidence of neonatal adverse outcomes in the experimental group was 7.14%， which was significantly lower than that in the conventional group （23.81%， P <0.05）. Conclusion Labetalol and magnesium sulfate can effectively control blood pressure， reduce 24-hour urinary protein and serum uric acid levels， andimprove adverse delivery outcomes and neonatal outcomes， which play a certain intervention role.

[Key words] Delivery outcome; Preeclampsia; Labetalol; Magnesium sulfate; Fetal distress

妊娠期高血压是孕妇所特有且较为常见的一种能够对其生命安全产生威胁的产科并发症，同样其也是引起低出生体重及早产等不良出生结局和围产儿死亡的重要因素之一[1]。当前临床对子痫前期发病因素尚未完全明确，认为可能同孕妇机体无法耐受妊娠负担，进而出现各种功能障碍相关，属于一种综合征，并且可出现浮肿、蛋白尿及高血压等临床表现[2]。因血压水平持续升高，会对胎盘血管造成损伤，导致胎盘早期剥离。在患病期间，由于胎盘无法获得足够血液供应，则会对胎儿机体生长发育产生不利影响。因此，在确诊疾病后需及时采取有效措施治疗。伴随临床对子痫前期研究的不断深入，发现在疾病发生发展过程中，血管内皮系统和氧化应激反应起到重要作用[3]。……