王婷婷

摘要：目的 观察女性围绝经期选择帕罗西汀联合心理治疗方案的效果，并分析对患者血清性激素水平、情绪障碍、睡眠质量的影响。方法 92研究对象，随机抽签法分为两组。两组均实施心理治疗，观察组加用帕罗西汀治疗，对比两组治疗后患者情绪、睡眠质量和血清激素水平变化。结果 治疗后相比于对照组，观察组负性情绪评分较低，睡眠质量评分较高（P<0.05）;两组干预后血清性激素水平均优于干预前但组间无明显差异（P<0.05）。结论 女性围绝经期选择帕罗西汀联合心理治疗，可改善患者情绪障碍和血清性激素水平，提升其睡眠质量，临床效果显著值得借鉴。

关键词：帕罗西汀;心理治疗;围绝经期;情绪障碍;睡眠质量;血清性激素水平

[Abstract]Objective To observe the effect of Paroxetine Combined with psychotherapy in women during perimenopause and analyze the influence on serum sex hormone level，emotional disorder and sleep quality. Methods 92 the subjects were divided into two groups by random drawing. The two groups were treated with psychotherapy. The observation group was treated with paroxetine. The changes of mood，sleep quality and serum hormone level were compared between the two groups. Results compared with the control group，the negative emotion score of observation group was lower and sleep quality score was higher（P < 0.05）;The serum sex hormone levels of the two groups were better than before intervention，but there was no significant difference between the two groups（P < 0.05）. Conclusion Paroxetine Combined with psychotherapy can improve the emotional disorder and serum sex hormone level and improve the sleep quality of women during perimenopause.

[Key words]paroxetine;psychotherapy;Perimenopause;Emotional disorder;Sleep quality;Serum sex hormone level

围绝经期也被称之为更年期，指的是女性存在和绝经相关的综合表现直至绝经后的1年这一时间段。此阶段内，体内激素水平存在明显变化，会导致自身的代谢、内分泌、精神、神经和心理等发生不同程度的变化【1】。专业研究结果提示，世界范围内75%-85%的女性，围绝经期会变存在头疼、疲乏、情绪异常、睡眠质量差等表现，情况严重时甚至会诱发器质性病变或是精神异常。目前，临床中针对围绝经期典型症状多选择雌激素替代疗法、无羟色胺再摄取抑制剂疗法和心理治疗等，可获得一定效果【2】。本次研究对本院接受治疗的围绝经期女性患者，在心理治疗基础上联合帕罗西汀治疗，重点观察治疗方案对患者血清性激素水平、情绪和睡眠的影响。……