王文静 陈鹏 李海洋 郑修文

【摘 要】 目的：基于数据挖掘技术分析温病四大家治疗暑温病的用药规律，为临床应用温病学说治疗暑温病提供参考。方法：收集温病四大家治疗暑温病的处方，借助 SPSS 25.0 IBM SPSS Modeler 18 计算机软件对处方进行用药频数分析、聚类分析、高频用药关联规则分析等，并结合温病四大家的学术观点，分析药物使用频次、配伍规律等。结果：数据挖掘结果表明，155首处方中使用频次在10以上的中药共39味;聚类分析可将高频使用中药聚为29类;关联规则分析显示，石膏-知母、滑石-杏仁，石膏-知母-甘草，石膏-知母-竹叶为较常用药对。结论：温病四大家在治疗暑温病时既遵循“清暑泄热”的治疗原则，又注重化湿祛湿，顾护气阴，以此来达到治愈之目的。

【关键词】 暑温;温病四大家;用药规律;数据挖掘

【中图分类号】R22 【文献标志码】 A 【文章编号】1007-8517（2021）13-0001-04

Abstract：Objective to analyze the medication rules of four eminent physicians of Seasonal Febrile Diseases in the treatment of summer-wen based on data mining technology，so as to provide theoretical guidance for clinical application of the theory of summer-wen.Methods the prescriptions of four eminent physicians of Seasonal Febrile Diseases in the treatment of summer-wen were collected and analyzed by SPSS 25.0 IBM SPSS modeler 18 computer software to analyze the frequency of drug use，cluster analysis，association rule analysis of high-frequency drugs，and combined with the academic views of four eminent physicians of Seasonal Febrile Diseases，the frequency of drug use and the rule of compatibility were analyzed.Results the results of data mining showed that there were 39 kinds of traditional Chinese medicine used more than 10 times in 155 prescriptions; cluster analysis could cluster the high-frequency Chinese medicine into 29 categories; association rule analysis showed that gypsum Anemarrhena，talcum almond，gypsum Anemarrhena Glycyrrhiza，gypsum Anemarrhena Rhizoma bamboo leaf were the more common drug pairs.Conclusion four eminent physicians of Seasonal Febrile Diseases not only follow the principle of “clearing heat and releasing heat”，but also pay attention to resolving dampness and removing dampness，taking care of Qi and Yin，so as to achieve curative effect.

Keywords：Summer-we;Four Eminent Physicians of Seasonal Febrile Diseases;Medication Rule;Data Mining

暑溫病，是由于感受暑热病邪所引起的一种急性外感热病[1-2]。暑温病的病因是暑热病邪，暑热侵犯人体多直入阳明，很少见到卫分证，初起就可见壮热、汗多、口渴等症状。由于暑热的火热之性较强，在疾病的发展过程中，容易造成患者耗气伤津，严重者可致津气欲脱等危重证候[3]。加之暑热亢盛，与心气相通，又易出现内闭心包等危候。暑热亢盛还可以动风、动血，造成肝风内动、肺伤络血等重证。如果暑热夹杂湿邪，又可出现暑湿困阻中焦、暑湿蒸腾弥漫三焦等证候[4]。

由于其致病因素特殊，临床表现危急，故及时有效地治疗暑温病，防止其进一步向危重症发展，成为目前临床上急需解决的难题。……