李娟

摘要：目的：探析对慢性阻塞性肺疾病合并呼吸衰竭应用无创呼吸机治疗的效果、不良反应。方法：将我院2018年7月到2020年6月收治的68例慢性阻塞性肺疾病合并呼吸衰竭患者纳入本次的研究范围，按照抽签法分为2组。对照组34例患者进行常规治疗，观察组34例患者则在对照组基础上加用无创呼吸机治疗。对比两组的住院时间、治疗前后的血气分析、肺功能情况及治疗后的并发症发生情况。结果：观察组住院时间短于对照组，PaCO2低于对照组，PaO2、pH值、FEV1、FCV、FEV1/FVC及不良反应发生率高于对照组，差异有统计学意义（P<0.05）。结论：对慢性阻塞性肺疾病合并呼吸衰竭患者应用无创呼吸机治疗具有显著的效果，能更好地改善患者的肺功能，缓解其症状，但容易发生呼吸机相关的不良反应，临床应采取有效措施降低不良反应发生的风险。

关键词：慢性阻塞性肺疾病;呼吸衰竭;无创呼吸机;有效性;安全性

Abstract： Objective： To investigate the effects and adverse reactions of non-invasive ventilator in the treatment of chronic obstructive pulmonary disease with respiratory failure. Methods： 68 patients with chronic obstructive pulmonary disease complicated with respiratory failure admitted to our hospital from July 2018 to June 2020 were included in the scope of this study， and were divided into two groups according to the lottery method. 34 patients in the control group received routine treatment， while 34 patients in the observation group were treated with non-invasive ventilator on the basis of the control group. The length of hospital stay， blood gas analysis before and after treatment， pulmonary function and complications after treatment were compared between the two groups. Results： The hospitalization time of the observation group was shorter than that of the control group， PaCO2 was lower than that of the control group， and the incidence of PaO2， pH， FEV1， FCV， FEV1/FVC and adverse reactions was higher than that of the control group， with statistically significant differences （P < 0.05）. Conclusion： Non-invasive ventilator therapy has a significant effect on patients with chronic obstructive pulmonary disease complicated with respiratory failure， which can better improve patients' lung function and relieve their symptoms， but ventilator related adverse reactions are easy to occur， and effective measures should be taken to reduce the risk of adverse reactions clinically.

Key words： chronic obstructive pulmonary disease; Respiratory failure; Non-invasive ventilator; Effectiveness; security

【中圖分类号】R563 【文献标识码】A 【文章编号】1673-9026（2021）08-203-01

前言

慢性阻塞性肺疾病是临床常见的呼吸系统疾病，以气流阻塞为主要病理特征，患者可出现胸闷、气喘、呼吸困难等情况，随着病情的发展，可合并呼吸衰竭[1]。采取常规方式治疗后无法获得满意的疗效，患者症状和各项实验室指标改善不明显，需配合无创呼吸机改善患者的肺通气功能，缓解其症状[2]。为探讨对慢性阻塞性肺疾病合并呼吸衰竭应用无创呼吸机治疗的疗效，本文选择68例患者进行研究，观察其治疗情况，并对无创呼吸机治疗慢性阻塞性肺疾病合并呼吸衰竭的有效性、安全性进行分析，全文如下。

正文

1 资料和方法

1.1 基线资料

本次研究的慢性阻塞性肺疾病合并呼吸衰竭患者均于2018年7月到2020年6月收治，病例总数为68例。将所有患者按照抽……