胡一川

[關键词] 非增生性;糖尿病视网膜病变;羟苯磺酸钙;阿卡波糖;二甲双胍

[中图分类号] R587.1          [文献标识码] A          [文章编号] 1673-9701（2021）19-0018-04

Efficacy of calcium dobesilate in the treatment of non-proliferative diabetic retinopathy

HU Yichuan

Department of Endocrinology， the Affiliated Shuyang Hospital of Xuzhou Medical University（Shuyang People′s Hospital）， Shuyang   223600， China

[Abstract] Objective To observe the clinical efficacy of calcium dobesilate in the treatment of non-proliferative diabetic retinopathy （NPDR）. Methods Sixty-four NPDR patients admitted to our hospital from January 2018 to April 2020 were selected. They were randomly divided into the observation group and the control group， with 32 cases in each group. Patients in the control group were given basic treatment， while patients in the observation group were given calcium dobesilate and basic treatment. The clinical efficacy of the two groups after treatment was evaluated. The blood glucose of the two groups before and after treatment was detected. The visual acuity， the number of microhemangioma， the area of bleeding spots and the thickness of macula were detected before and after treatment. The adverse reactions （ADRs） of the two groups were observed. Results ①The total effective rate of the observation group was 93.75%（30/32）， which was significantly higher than that of the control group （71.88%， 23/32）（P<0.05）. ②There were no statistically significant differences in the levels of fasting blood glucose， 2 hour postprandial blood glucose and glycosylated hemoglobin between the two groups before and after treatment （P>0.05）.③Before treatment， there were no statistically significant differences in the visual acuity，the number of microhemangioma， the area of bleeding spots and the thickness of macula between the two groups（P>0.05）.After treatment， the visual acuity，the number of microhemangioma， the area of bleeding spots and the thickness of macula in the two groups were significantly improved compared with those before treatment， the visual acuity in the observation group was higher than that in the control group，the number of microvessels，the area of bleeding spots and the thickness of macula in the observation group was less than that in the control group（P<0.05）.④There was no significant difference in the incidence of ADRs between the two groups [15.62% （5/32） vs. 12.50% （4/32）]（P>0.05）. Conclusion Calcium dobesilate can improve NPDR and improve clinical efficacy， which is worthy of popularization and application.